Aspirin improves uterine blood flow in the peri-implantation period

Hong Chang Kuo, Chao Chin Hsu*, Shan Tair Wang, Ko En Huang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

26 Scopus citations

Abstract

A prospective clinical study at the Infertility Clinic of National Cheng Kung University Hospital investigated the effect of aspirin on infertile women with impaired uterine perfusion. A total of 127 women with unexplained infertility or repeated failure with various assisted-conception techniques were enrolled. Uterine perfusion was assessed by Doppler ultrasound and classified as normal or impaired (pulsatility index <3.0 or ≤3.0, respectively). One-third (43/127) of the women were found to have impaired uterine perfusion during their menstrual cycles. Those with impaired uterine blood flow were given aspirin (100 mg/day) starting on day 3 of the next ovulatory cycle. Only 36 women completed both the screening and the aspirin-treated cycles. The pulsatility index was measured in the natural and aspirin-treated cycles in the same group of women and compared using repeated measures analyses of variance. A significant improvement in the uterine blood perfusion (p < 0.05) was detected on the day leutinizing hormone peaked and in the midluteal phase (peri-implantation period) of aspirin-treated cycles. Thus, the use of low-dose aspirin may improve uterine perfusion in women with unexplained infertility and impaired uterine blood flow.

Original languageEnglish
Pages (from-to)253-257
Number of pages5
JournalJournal of the Formosan Medical Association
Volume96
Issue number4
StatePublished - 04 1997
Externally publishedYes

Keywords

  • aspirin
  • in vitro fertilization
  • infertility
  • midluteal phase
  • peri-implantation
  • uterine perfusion

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