Assessing neuroreceptor occupancy by continuous infusion of carbon-11 labeled radioligands

Pan Fu Kao; Stanley Kim; Henry N. Wagner; John R. Lever; Hayden T. Ravert; Robert F. Dannals

doi:10.1007/BF01731836

Assessing neuroreceptor occupancy by continuous infusion of carbon-11 labeled radioligands

Pan Fu Kao, Stanley Kim, Henry N. Wagner^*, John R. Lever, Hayden T. Ravert, Robert F. Dannals

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

2 Scopus citations

Abstract

In carbon-11 labeled radiotracer studies of neuroreceptors in the brain, a state of practical equilibrium, monitored with a simple dual-probe detector system, was achieved by injection of a bolus of tracer followed by a continuous infusion of the tracer. After investigating several different bolus-to-infusion activity ratios, we observed that a practical equilibrium state could be achieved with a slope of 0.02 ± 0.001 cps x kg/μCi/min for [¹¹C]carfentanil studies in normal human beings. The usefulness of this approach to assess neuroreceptor occupancy was demonstrated in two cases.

Original language	English
Pages (from-to)	141-144
Number of pages	4
Journal	European Journal of Nuclear Medicine
Volume	23
Issue number	2
DOIs	https://doi.org/10.1007/BF01731836
State	Published - 1996
Externally published	Yes

Keywords

Carbon-11 radioligands
Continuous infusion
Dual-probe detector system
Equilibrium state

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10.1007/BF01731836

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title = "Assessing neuroreceptor occupancy by continuous infusion of carbon-11 labeled radioligands",

abstract = "In carbon-11 labeled radiotracer studies of neuroreceptors in the brain, a state of practical equilibrium, monitored with a simple dual-probe detector system, was achieved by injection of a bolus of tracer followed by a continuous infusion of the tracer. After investigating several different bolus-to-infusion activity ratios, we observed that a practical equilibrium state could be achieved with a slope of 0.02 ± 0.001 cps x kg/μCi/min for [11C]carfentanil studies in normal human beings. The usefulness of this approach to assess neuroreceptor occupancy was demonstrated in two cases.",

keywords = "Carbon-11 radioligands, Continuous infusion, Dual-probe detector system, Equilibrium state",

author = "Kao, {Pan Fu} and Stanley Kim and Wagner, {Henry N.} and Lever, {John R.} and Ravert, {Hayden T.} and Dannals, {Robert F.}",

year = "1996",

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journal = "European Journal of Nuclear Medicine",

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T1 - Assessing neuroreceptor occupancy by continuous infusion of carbon-11 labeled radioligands

AU - Kao, Pan Fu

AU - Kim, Stanley

AU - Wagner, Henry N.

AU - Lever, John R.

AU - Ravert, Hayden T.

AU - Dannals, Robert F.

PY - 1996

Y1 - 1996

N2 - In carbon-11 labeled radiotracer studies of neuroreceptors in the brain, a state of practical equilibrium, monitored with a simple dual-probe detector system, was achieved by injection of a bolus of tracer followed by a continuous infusion of the tracer. After investigating several different bolus-to-infusion activity ratios, we observed that a practical equilibrium state could be achieved with a slope of 0.02 ± 0.001 cps x kg/μCi/min for [11C]carfentanil studies in normal human beings. The usefulness of this approach to assess neuroreceptor occupancy was demonstrated in two cases.

AB - In carbon-11 labeled radiotracer studies of neuroreceptors in the brain, a state of practical equilibrium, monitored with a simple dual-probe detector system, was achieved by injection of a bolus of tracer followed by a continuous infusion of the tracer. After investigating several different bolus-to-infusion activity ratios, we observed that a practical equilibrium state could be achieved with a slope of 0.02 ± 0.001 cps x kg/μCi/min for [11C]carfentanil studies in normal human beings. The usefulness of this approach to assess neuroreceptor occupancy was demonstrated in two cases.

KW - Carbon-11 radioligands

KW - Continuous infusion

KW - Dual-probe detector system

KW - Equilibrium state

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DO - 10.1007/BF01731836

M3 - 文章

C2 - 8925847

AN - SCOPUS:0030062171

SN - 0340-6997

VL - 23

SP - 141

EP - 144

JO - European Journal of Nuclear Medicine

JF - European Journal of Nuclear Medicine

IS - 2

ER -

Assessing neuroreceptor occupancy by continuous infusion of carbon-11 labeled radioligands

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Keywords

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