Assessment of vessel permeability by combining dynamic contrast-enhanced and arterial spin labeling MRI

Ho Ling Liu, Ting Ting Chang, Feng Xian Yan, Cheng He Li, Yu Shi Lin, Alex M. Wong*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations

Abstract

The forward volumetric transfer constant (Ktrans), a physiological parameter extracted from dynamic contrast-enhanced (DCE) MRI, is weighted by vessel permeability and tissue blood flow. The permeability×surface area product per unit mass of tissue (PS) in brain tumors was estimated in this study by combining the blood flow obtained through pseudo-continuous arterial spin labeling (PCASL) and Ktrans obtained through DCE MRI. An analytical analysis and a numerical simulation were conducted to understand how errors in the flow and Ktrans estimates would propagate to the resulting PS. Fourteen pediatric patients with brain tumors were scanned on a clinical 3-T MRI scanner. PCASL perfusion imaging was performed using a three-dimensional (3D) fast-spin-echo readout module to determine blood flow. DCE imaging was performed using a 3D spoiled gradient-echo sequence, and the Ktrans map was obtained with the extended Tofts model. The numerical analysis demonstrated that the uncertainty of PS was predominantly dependent on that of Ktrans and was relatively insensitive to the flow. The average PS values of the whole tumors ranged from 0.006 to 0.217min-1, with a mean of 0.050min-1 among the patients. The mean Ktrans value was 18% lower than the PS value, with a maximum discrepancy of 25%. When the parametric maps were compared on a voxel-by-voxel basis, the discrepancies between PS and Ktrans appeared to be heterogeneous within the tumors. The PS values could be more than two-fold higher than the Ktrans values for voxels with high Ktrans levels. This study proposes a method that is easy to implement in clinical practice and has the potential to improve the quantification of the microvascular properties of brain tumors.

Original languageEnglish
Pages (from-to)642-649
Number of pages8
JournalNMR in Biomedicine
Volume28
Issue number6
DOIs
StatePublished - 01 06 2015

Bibliographical note

Publisher Copyright:
© 2015 John Wiley & Sons, Ltd.

Keywords

  • Arterial spin labeling (ASL)
  • Dynamic contrast enhanced (DCE)
  • Forward volumetric transfer constant (K)
  • MRI
  • Permeability

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