Association between ambient particulate matter 2.5 exposure and mortality in patients with hepatocellular carcinoma

Chern Horng Lee; Sen Yung Hsieh; Wen Hung Huang; I. Kuan Wang; Tzung Hai Yen

doi:10.3390/ijerph16142490

Association between ambient particulate matter 2.5 exposure and mortality in patients with hepatocellular carcinoma

Chern Horng Lee, Sen Yung Hsieh, Wen Hung Huang, I. Kuan Wang, Tzung Hai Yen^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

16 Scopus citations

Abstract

Air pollution is a severe public health problem in Taiwan. Moreover, Taiwan is an endemic area for hepatocellular carcinoma (HCC). This study examined the effect of particulate matter 2.5 (PM_2.5) exposure on mortality in this population. A total of 1003 patients with HCC treated at Chang Gung Memorial Hospital between 2000 and 2009 were included in this study. At the end of the analysis, 288 (28.7%) patients had died. Patients with HCC living in environments with PM_2.5 concentrations of ≥36 µg/m³ had a higher mortality rate than patients living in environments with PM_2.5 concentrations of <36 µg/m³ (36.8% versus 27.5%, p = 0.034). The multivariate Cox regression analysis confirmed that PM_2.5 ≥ 36 µg/m³ was a significant risk factor for mortality (1.584 (1.162–2.160), p = 0.004). A nonlinear relationship was observed between the odds ratio and PM_2.5. The odds ratio was 1.137 (1.015–1.264) for each increment of 5 µg/m³ in PM_2.5 or 1.292 (1.030–1.598) for each increment of 10 µg/m³ in PM_2.5. Therefore, patients with HCC exposed to ambient PM_2.5 concentrations of ≥36 µg/m³ had a 1.584-fold higher risk of death than those exposed to PM_2.5 concentrations of <36 µg/m³. Further studies are warranted.

Original language	English
Article number	2490
Journal	International Journal of Environmental Research and Public Health
Volume	16
Issue number	14
DOIs	https://doi.org/10.3390/ijerph16142490
State	Published - 02 07 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Air pollution
Hepatocellular carcinoma
Mortality
PM
Particulate matter

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/ijerph16142490

Cite this

@article{6553aa92fdcb4d4f80bcc20111f0e550,

title = "Association between ambient particulate matter 2.5 exposure and mortality in patients with hepatocellular carcinoma",

abstract = "Air pollution is a severe public health problem in Taiwan. Moreover, Taiwan is an endemic area for hepatocellular carcinoma (HCC). This study examined the effect of particulate matter 2.5 (PM2.5) exposure on mortality in this population. A total of 1003 patients with HCC treated at Chang Gung Memorial Hospital between 2000 and 2009 were included in this study. At the end of the analysis, 288 (28.7%) patients had died. Patients with HCC living in environments with PM2.5 concentrations of ≥36 µg/m3 had a higher mortality rate than patients living in environments with PM2.5 concentrations of <36 µg/m3 (36.8% versus 27.5%, p = 0.034). The multivariate Cox regression analysis confirmed that PM2.5 ≥ 36 µg/m3 was a significant risk factor for mortality (1.584 (1.162–2.160), p = 0.004). A nonlinear relationship was observed between the odds ratio and PM2.5. The odds ratio was 1.137 (1.015–1.264) for each increment of 5 µg/m3 in PM2.5 or 1.292 (1.030–1.598) for each increment of 10 µg/m3 in PM2.5. Therefore, patients with HCC exposed to ambient PM2.5 concentrations of ≥36 µg/m3 had a 1.584-fold higher risk of death than those exposed to PM2.5 concentrations of <36 µg/m3. Further studies are warranted.",

keywords = "Air pollution, Hepatocellular carcinoma, Mortality, PM, Particulate matter",

author = "Lee, {Chern Horng} and Hsieh, {Sen Yung} and Huang, {Wen Hung} and Wang, {I. Kuan} and Yen, {Tzung Hai}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = jul,

day = "2",

doi = "10.3390/ijerph16142490",

language = "英语",

volume = "16",

journal = "International Journal of Environmental Research and Public Health",

issn = "1661-7827",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "14",

}

TY - JOUR

T1 - Association between ambient particulate matter 2.5 exposure and mortality in patients with hepatocellular carcinoma

AU - Lee, Chern Horng

AU - Hsieh, Sen Yung

AU - Huang, Wen Hung

AU - Wang, I. Kuan

AU - Yen, Tzung Hai

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Air pollution is a severe public health problem in Taiwan. Moreover, Taiwan is an endemic area for hepatocellular carcinoma (HCC). This study examined the effect of particulate matter 2.5 (PM2.5) exposure on mortality in this population. A total of 1003 patients with HCC treated at Chang Gung Memorial Hospital between 2000 and 2009 were included in this study. At the end of the analysis, 288 (28.7%) patients had died. Patients with HCC living in environments with PM2.5 concentrations of ≥36 µg/m3 had a higher mortality rate than patients living in environments with PM2.5 concentrations of <36 µg/m3 (36.8% versus 27.5%, p = 0.034). The multivariate Cox regression analysis confirmed that PM2.5 ≥ 36 µg/m3 was a significant risk factor for mortality (1.584 (1.162–2.160), p = 0.004). A nonlinear relationship was observed between the odds ratio and PM2.5. The odds ratio was 1.137 (1.015–1.264) for each increment of 5 µg/m3 in PM2.5 or 1.292 (1.030–1.598) for each increment of 10 µg/m3 in PM2.5. Therefore, patients with HCC exposed to ambient PM2.5 concentrations of ≥36 µg/m3 had a 1.584-fold higher risk of death than those exposed to PM2.5 concentrations of <36 µg/m3. Further studies are warranted.

AB - Air pollution is a severe public health problem in Taiwan. Moreover, Taiwan is an endemic area for hepatocellular carcinoma (HCC). This study examined the effect of particulate matter 2.5 (PM2.5) exposure on mortality in this population. A total of 1003 patients with HCC treated at Chang Gung Memorial Hospital between 2000 and 2009 were included in this study. At the end of the analysis, 288 (28.7%) patients had died. Patients with HCC living in environments with PM2.5 concentrations of ≥36 µg/m3 had a higher mortality rate than patients living in environments with PM2.5 concentrations of <36 µg/m3 (36.8% versus 27.5%, p = 0.034). The multivariate Cox regression analysis confirmed that PM2.5 ≥ 36 µg/m3 was a significant risk factor for mortality (1.584 (1.162–2.160), p = 0.004). A nonlinear relationship was observed between the odds ratio and PM2.5. The odds ratio was 1.137 (1.015–1.264) for each increment of 5 µg/m3 in PM2.5 or 1.292 (1.030–1.598) for each increment of 10 µg/m3 in PM2.5. Therefore, patients with HCC exposed to ambient PM2.5 concentrations of ≥36 µg/m3 had a 1.584-fold higher risk of death than those exposed to PM2.5 concentrations of <36 µg/m3. Further studies are warranted.

KW - Air pollution

KW - Hepatocellular carcinoma

KW - Mortality

KW - PM

KW - Particulate matter

UR - http://www.scopus.com/inward/record.url?scp=85070403805&partnerID=8YFLogxK

U2 - 10.3390/ijerph16142490

DO - 10.3390/ijerph16142490

M3 - 文章

C2 - 31336910

AN - SCOPUS:85070403805

SN - 1661-7827

VL - 16

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

IS - 14

M1 - 2490

ER -

Association between ambient particulate matter 2.5 exposure and mortality in patients with hepatocellular carcinoma

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this