TY - JOUR
T1 - Association between chronic idiopathic urticaria and hypertension A population-based retrospective cohort study
AU - Chang, Heng Wei
AU - Cheng, Hui Man
AU - Yen, Hung Rong
AU - Hsu, Chung Y.
AU - Lee, Yu Chen
AU - Chiang, Jen Huai
AU - Sun, Mao Feng
N1 - Publisher Copyright:
© 2016 American College of Allergy, Asthma & Immunology.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Background Chronic idiopathic urticaria (CIU) is defined as urticaria that is not caused by external triggers. The pathogenesis of CIU remains unknown. A previous study investigated whether hypertension is associated with extended duration of CIU. Objective To investigate the possible association between CIU and hypertension. Methods We performed a population-based retrospective cohort study of 2,460 patients with CIU and 9,840 age-, sex-, and index year-matched comparison patients, using the National Health Insurance of Taiwan database. The median follow-up periods were 7.13 years for the CIU cohort and 7.20 years for the non-CIU cohort. The distributions by sex and age were similar for both cohorts. Results The CIU cohort had a 1.37-fold (95% CI, 1.22-1.53) greater risk of developing subsequent hypertension than the non-CIU cohort after adjusting for sex, age, comorbidities, and nonsedating antihistamine use. Conclusion This nationwide retrospective cohort study found that CIU is associated with a higher future risk of hypertension after adjusting for sex, age, comorbidities, and nonsedating antihistamine use. The detailed pathophysiologic mechanisms require further clarification in prospective studies.
AB - Background Chronic idiopathic urticaria (CIU) is defined as urticaria that is not caused by external triggers. The pathogenesis of CIU remains unknown. A previous study investigated whether hypertension is associated with extended duration of CIU. Objective To investigate the possible association between CIU and hypertension. Methods We performed a population-based retrospective cohort study of 2,460 patients with CIU and 9,840 age-, sex-, and index year-matched comparison patients, using the National Health Insurance of Taiwan database. The median follow-up periods were 7.13 years for the CIU cohort and 7.20 years for the non-CIU cohort. The distributions by sex and age were similar for both cohorts. Results The CIU cohort had a 1.37-fold (95% CI, 1.22-1.53) greater risk of developing subsequent hypertension than the non-CIU cohort after adjusting for sex, age, comorbidities, and nonsedating antihistamine use. Conclusion This nationwide retrospective cohort study found that CIU is associated with a higher future risk of hypertension after adjusting for sex, age, comorbidities, and nonsedating antihistamine use. The detailed pathophysiologic mechanisms require further clarification in prospective studies.
UR - https://www.scopus.com/pages/publications/84971671269
U2 - 10.1016/j.anai.2016.04.001
DO - 10.1016/j.anai.2016.04.001
M3 - 文章
C2 - 27264565
AN - SCOPUS:84971671269
SN - 1081-1206
VL - 116
SP - 554
EP - 558
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 6
ER -
