Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility

Da Tian Bau*, Chao Hsiang Chang, Ming Hsui Tsai, Chang Fang Chiu, Yung An Tsou, Rou Fen Wang, Chia Wen Tsai, Ru Yin Tsai

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

42 Scopus citations

Abstract

Objectives/Hypothesis: The ataxia-telangiectasia mutated (ATM) is thought to play a major role in the caretaking of the overall genome stability, and its mutations have been implicated in human cancers. However, the role of ATM polymorphisms in oral carcinogenesis is largely unexplored. Thus, the polymorphic variants of ATM were first investigated for their association with oral cancer susceptibility. Study Design: In this hospital-based, case-control study, associations of seven ATM single nucleotide polymorphisms with oral cancer risk in a Taiwanese population were investigated. Methods: A total of 620 patients with oral cancer and 620 healthy controls were genotyped and analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. Results: There were significant differences between oral cancer and control groups in the distributions of their genotypes (P = 3.71E-6) and allelic frequencies (P = 5.09E-6) in the ATM rs189037 polymorphisms. In the other six polymorphisms, there was no differential distribution between both groups. There are synergistic joint interactions of ATM genotyping with smoking, alcohol drinking, and betel quid chewing. Conclusions: The ATM rs189037 A allele is correlated with oral cancer susceptibility, and this polymorphism may be a useful marker for oral cancer prevention and early detection.

Original languageEnglish
Pages (from-to)2417-2422
Number of pages6
JournalLaryngoscope
Volume120
Issue number12
DOIs
StatePublished - 12 2010
Externally publishedYes

Keywords

  • ATM
  • betel quid
  • carcinogenesis
  • oral cancer
  • polymorphism

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