Association between erectile dysfunction and fibromyalgia in male patients: A Taiwanese nationwide population-based cohort study

Shi Chen Ou, Mei Chen Lin, Hung Jen Lin, Chi Ping Huang, Sheng Teng Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


Objectives: To investigate the association between erectile dysfunction and fibromyalgia, and to clarify related comorbidities and treatment modalities. Methods: This retrospective cohort study was carried out using 1 million records in the National Health Insurance Research Database. From 2001 to 2012, a total of 53 678 male patients newly diagnosed with fibromyalgia were recruited as the fibromyalgia cohort, and the same number of the non-fibromyalgia cohort was enrolled and matched with propensity score with age, income, comorbidities, and prescribed medications. All records were followed up until the end of 2013. The Cox proportional hazards model was carried out to assess the risk of erectile dysfunction among fibromyalgia patients. Results: The incidence rates of erectile dysfunction were 36.86 and 21.15 (per 10 000 person-years) in the fibromyalgia and non-fibromyalgia cohorts, respectively, and a significantly increased risk of erectile dysfunction in fibromyalgia patients was noted (adjusted hazard ratio 1.69, 95% confidence interval 1.55–1.85, P < 0.001). The Cox proportional hazards regression analysis showed increased risk of erectile dysfunction in the fibromyalgia cohort regardless of treatment prescriptions of tramadol, antidepressants, gabapentin and non-steroidal anti-inflammatory drugs. Conclusions: Fibromyalgia was found to be an independent risk factor for the incidence of erectile dysfunction.

Original languageEnglish
Pages (from-to)1102-1108
Number of pages7
JournalInternational Journal of Urology
Issue number12
StatePublished - 12 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 The Japanese Urological Association


  • National Health Insurance Research Database
  • antidepressive agents
  • erectile dysfunction
  • fibromyalgia
  • retrospective cohort study


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