TY - JOUR
T1 - Association between Hemodiafiltration and Hypoalbuminemia in Middle-Age Hemodialysis Patients
AU - Weng, Shih-Hwa
AU - Hsu, Ching Wei
AU - Hu, Ching Chih
AU - Yen, Tzung Hai
AU - Huang, Wen Hung
N1 - Publisher Copyright:
© 2016 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - The advantage of hemodiafiltration (HDF) is well known. One of the disadvantages of HDF is loss of serum albumin, but this issue is still obscure. Some risk factors associated with mortality were age dependent. Studies on serum albumin/hypoalbuminemia and HDF in different age stratification were limited. The aim of this cross-sectional study was to assess the role of HDF and other clinical variables on serum albumin values in maintenance hemodialysis (MHD) patients of different age groups. We recruited a total of 1216 patients on MHD. Patients were divided into 4 groups by age stratification of youth (<30years old), young-middle age (30-44years old), middle age (45-64years old), and old age (≥65 years old). Biochemical, hematological, nutritional, inflammatory parameters, and receiving HDF or not were recorded. The associations between age groups, HDF, and variables mentioned above were analyzed. Only in middle-age group, patients with HDF was significantly (P=0.013) associated with serum albumin <4g/dL. In middle-age group, a multivariate-forward logistic regression analysis showed that male sex (2.169 [1.029, 4.574], P=0.042), inflammation (4.167 [2.043, 8.498], P<0.001), cardiovascular disease (2.92 [1.019, 8.402], P=0.046), serum creatinine level (0.639 [0.538, 0.758], P<0.001), and cholesterol level (0.984 [0.975, 0.993], P=0.001) were associated with serum albumin level <3.6g/dL. Hepatitis C virus infection (1.911 [1.186, 3.077], P=0.008), HDF (2.143 [1.298, 3.540], P=0.003), inflammation (2.309 [1.549, 3.440], P<0.001), use of arterio-venous fistula (0.518 [0.327, 0.820], P=0.005), Kt/V (0.395 [0.193, 0.809], P=0.011), nonanuria (0.542 [0.337, 0.870], P=0.011), serum creatinine level (0.744 [0.669, 0.828], P<0.001), and cholesterol level (0.993 [0.987, 0.998], P=0.013) were associated with serum albumin level <4g/dL. HDF can predict serum albumin level <4g/dL in middle-age HD patients. The effect of age needs to be taken into consideration when interpreting the correlation between hypoalbuminemia and HDF.
AB - The advantage of hemodiafiltration (HDF) is well known. One of the disadvantages of HDF is loss of serum albumin, but this issue is still obscure. Some risk factors associated with mortality were age dependent. Studies on serum albumin/hypoalbuminemia and HDF in different age stratification were limited. The aim of this cross-sectional study was to assess the role of HDF and other clinical variables on serum albumin values in maintenance hemodialysis (MHD) patients of different age groups. We recruited a total of 1216 patients on MHD. Patients were divided into 4 groups by age stratification of youth (<30years old), young-middle age (30-44years old), middle age (45-64years old), and old age (≥65 years old). Biochemical, hematological, nutritional, inflammatory parameters, and receiving HDF or not were recorded. The associations between age groups, HDF, and variables mentioned above were analyzed. Only in middle-age group, patients with HDF was significantly (P=0.013) associated with serum albumin <4g/dL. In middle-age group, a multivariate-forward logistic regression analysis showed that male sex (2.169 [1.029, 4.574], P=0.042), inflammation (4.167 [2.043, 8.498], P<0.001), cardiovascular disease (2.92 [1.019, 8.402], P=0.046), serum creatinine level (0.639 [0.538, 0.758], P<0.001), and cholesterol level (0.984 [0.975, 0.993], P=0.001) were associated with serum albumin level <3.6g/dL. Hepatitis C virus infection (1.911 [1.186, 3.077], P=0.008), HDF (2.143 [1.298, 3.540], P=0.003), inflammation (2.309 [1.549, 3.440], P<0.001), use of arterio-venous fistula (0.518 [0.327, 0.820], P=0.005), Kt/V (0.395 [0.193, 0.809], P=0.011), nonanuria (0.542 [0.337, 0.870], P=0.011), serum creatinine level (0.744 [0.669, 0.828], P<0.001), and cholesterol level (0.993 [0.987, 0.998], P=0.013) were associated with serum albumin level <4g/dL. HDF can predict serum albumin level <4g/dL in middle-age HD patients. The effect of age needs to be taken into consideration when interpreting the correlation between hypoalbuminemia and HDF.
UR - http://www.scopus.com/inward/record.url?scp=84964659503&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000003334
DO - 10.1097/MD.0000000000003334
M3 - 文章
C2 - 27082584
AN - SCOPUS:84964659503
SN - 0025-7974
VL - 95
JO - Medicine (United States)
JF - Medicine (United States)
IS - 15
M1 - e3334
ER -
