Association between interleukin-10 gene polymorphism -592 (A/C) and peritoneal transport in patients undergoing peritoneal dialysis.

YT Lee, YC Tsai, YK Yang, KT Hsu, SC Liao, CH Wu, BC Cheng, JB Chen, Chih-Hung Lee, CT Lee

Research output: Contribution to journalJournal Article peer-review

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A total of 141 stable peritoneal dialysis (PD) patients with mean treatment duration of 84.4 ± 34.2 months were enrolled. We genotyped these three cytokine polymorphisms, together with clinical parameters that were included as factors affecting longitudinal change of property of peritoneal transport over the first 3 year period after commencing therapy. Single nucleotide polymorphism of IL-10 -592 (A/C) was associated with longitudinal evolution of peritoneal transport rate in PD patients rather than the baseline peritoneal characteristics. The aim of this analysis was to know whether these three cytokine polymorphisms, including interleukin-6 (IL-6; -572 G/C), tumour necrosis factor-α (TNF-α; -308 G/A), and IL-10 (-592 A/C) have an effect on baseline peritoneal transport property and longitudinal evolution of peritoneal function. There was no significant association between genotypes and baseline peritoneal transport property. The -592 A/C polymorphism of IL-10 was associated with longitudinal change of peritoneal transport. The ratio of D/P creatinine was significantly higher in patients with AA than those with CC/CA genotypes at 12 months (0.65 ± 0.11 vs 0.62 ± 0.09, P = 0.048) and 24 months (0.64 ± 0.12 vs 0.59 ± 0.09, P = 0.018). In addition, patients with increased peritoneal transport have greater frequency distribution of AA genotype and A allele. Logistic regression analysis revealed that -592 A allele was an independent predictor for the increase in D/P creatinine over the first 12 month period (odds ratio: 2.482, P = 0.017). There was no correlation between either polymorphism of IL-6 -572 (G/C) or TNF-α-308 (G/A) and longitudinal change of peritoneal function.
Original languageAmerican English
Pages (from-to)663-671
JournalNephrology (Carlton, Vic.)
Issue number7
StatePublished - 2011


  • Adult
  • Aged
  • Biological Transport
  • Chi-Square Distribution
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Interleukin-10/genetics
  • Interleukin-6/genetics
  • Kidney Failure, Chronic/genetics
  • Kidney Failure, Chronic/immunology
  • Kidney Failure, Chronic/metabolism
  • Kidney Failure, Chronic/therapy
  • Logistic Models
  • Male
  • Middle Aged
  • Peritoneal Dialysis
  • Peritoneum/metabolism
  • Permeability
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Retrospective Studies
  • Taiwan
  • Time Factors
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha/genetics


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