Association between periodontal pathogens and systemic disease

Fiona Q. Bui, Cassio Luiz Coutinho Almeida-da-Silva, Brandon Huynh, Alston Trinh, Jessica Liu, Jacob Woodward, Homer Asadi, David M. Ojcius*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

413 Scopus citations


A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoting the development of systemic conditions. A cause-and-effect relationship has not been established yet for most of the diseases, and the mediators of the association are still being identified. A better understanding of the systemic effects of oral microorganisms will contribute to the goal of using the oral cavity to diagnose and possibly treat non-oral systemic disease.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalBiomedical Journal
Issue number1
StatePublished - 02 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Chang Gung University


  • Chronic disease
  • Dentistry
  • Inflammation
  • Oral pathogens
  • Periodontal disease
  • Systemic disease


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