Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients

Ching Wei Hsu; Shih-Hwa Weng; Ming Jen Chan; Dan Tzu Lin-Tan; Tzung Hai Yen; Wen Hung Huang

doi:10.1038/s41598-018-35217-6

Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients

Ching Wei Hsu
, Shih-Hwa Weng
, Ming Jen Chan
, Dan Tzu Lin-Tan
, Tzung Hai Yen
, Wen Hung Huang^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

27 Scopus citations

Abstract

Uremic pruritus (UP) is a common symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is complex. Aluminum (Al) is a common metal and is toxic to patients undergoing HD. Al is also a known human allergen which can induce immune reactions. However, the correlation between Al and UP remains unclear in dialysis patients. A total of 866 patients on maintenance HD were enrolled for analysis. The HD patients with higher serum Al levels had higher a prevalence of UP than those with lower serum Al levels. After adjusting for confounding variables, the serum Al level was significantly associated with UP. Overall, each 10-fold increase in serum Al level was associated with a 5.64-fold increase in the risk of developing UP in these subjects. The results of this cross-sectional study suggest that serum Al level may be associated with the development of UP in patients on maintenance HD.

Original language	English
Article number	17251
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-35217-6
State	Published - 01 12 2018

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Publisher Copyright:
© 2018, The Author(s).

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title = "Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients",

abstract = "Uremic pruritus (UP) is a common symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is complex. Aluminum (Al) is a common metal and is toxic to patients undergoing HD. Al is also a known human allergen which can induce immune reactions. However, the correlation between Al and UP remains unclear in dialysis patients. A total of 866 patients on maintenance HD were enrolled for analysis. The HD patients with higher serum Al levels had higher a prevalence of UP than those with lower serum Al levels. After adjusting for confounding variables, the serum Al level was significantly associated with UP. Overall, each 10-fold increase in serum Al level was associated with a 5.64-fold increase in the risk of developing UP in these subjects. The results of this cross-sectional study suggest that serum Al level may be associated with the development of UP in patients on maintenance HD.",

author = "Hsu, \{Ching Wei\} and Shih-Hwa Weng and Chan, \{Ming Jen\} and Lin-Tan, \{Dan Tzu\} and Yen, \{Tzung Hai\} and Huang, \{Wen Hung\}",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

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doi = "10.1038/s41598-018-35217-6",

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AU - Hsu, Ching Wei

AU - Weng, Shih-Hwa

AU - Chan, Ming Jen

AU - Lin-Tan, Dan Tzu

AU - Yen, Tzung Hai

AU - Huang, Wen Hung

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Uremic pruritus (UP) is a common symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is complex. Aluminum (Al) is a common metal and is toxic to patients undergoing HD. Al is also a known human allergen which can induce immune reactions. However, the correlation between Al and UP remains unclear in dialysis patients. A total of 866 patients on maintenance HD were enrolled for analysis. The HD patients with higher serum Al levels had higher a prevalence of UP than those with lower serum Al levels. After adjusting for confounding variables, the serum Al level was significantly associated with UP. Overall, each 10-fold increase in serum Al level was associated with a 5.64-fold increase in the risk of developing UP in these subjects. The results of this cross-sectional study suggest that serum Al level may be associated with the development of UP in patients on maintenance HD.

AB - Uremic pruritus (UP) is a common symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is complex. Aluminum (Al) is a common metal and is toxic to patients undergoing HD. Al is also a known human allergen which can induce immune reactions. However, the correlation between Al and UP remains unclear in dialysis patients. A total of 866 patients on maintenance HD were enrolled for analysis. The HD patients with higher serum Al levels had higher a prevalence of UP than those with lower serum Al levels. After adjusting for confounding variables, the serum Al level was significantly associated with UP. Overall, each 10-fold increase in serum Al level was associated with a 5.64-fold increase in the risk of developing UP in these subjects. The results of this cross-sectional study suggest that serum Al level may be associated with the development of UP in patients on maintenance HD.

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DO - 10.1038/s41598-018-35217-6

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JO - Scientific Reports

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ER -

Association Between Serum Aluminum Level and Uremic Pruritus in Hemodialysis Patients

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