Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis

L. S. Ou; L. C. See; C. J. Wu; C. C. Kao; Y. L. Lin; J. L. Huang

doi:10.1007/s100670200012

Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis

L. S. Ou, L. C. See, C. J. Wu, C. C. Kao, Y. L. Lin, J. L. Huang^*

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

35 Scopus citations

Abstract

Circulating interleukin-1β (IL-1β), IL-6, tumour necrosis factor-α (TNF-α), osteocalcin, and conventional parameters of inflammation were examined serially in 14 children with juvenile idiopathic arthritis (JIA) to determine any correlation with the disease activity. Serum IL-1β was undetectable in all JIA patients. Serum IL-6, white blood cell counts, platelet counts, erythrocyte sedimentation rate and C-reactive protein levels were significantly elevated in the active phase of JIA, whereas hemoglobin levels were significantly lower. Osteocalcin levels were decreased and TNF-α increased in active JIA status, but these differences showed no statistical significance. We concluded that inflammatory cytokines play an important role in JIA. Monitoring IL-6 in children with JIA is useful in determining disease activity and response to therapy. These findings confirm earlier reports.

Original language	English
Pages (from-to)	52-56
Number of pages	5
Journal	Clinical Rheumatology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/s100670200012
State	Published - 2002

Keywords

Cytokine
IL-1
IL-6
Juvenile idiopathic arthritis
Juvenile rheumatoid arthritis
Osteocalcin
TNF-α

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10.1007/s100670200012

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title = "Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis",

abstract = "Circulating interleukin-1β (IL-1β), IL-6, tumour necrosis factor-α (TNF-α), osteocalcin, and conventional parameters of inflammation were examined serially in 14 children with juvenile idiopathic arthritis (JIA) to determine any correlation with the disease activity. Serum IL-1β was undetectable in all JIA patients. Serum IL-6, white blood cell counts, platelet counts, erythrocyte sedimentation rate and C-reactive protein levels were significantly elevated in the active phase of JIA, whereas hemoglobin levels were significantly lower. Osteocalcin levels were decreased and TNF-α increased in active JIA status, but these differences showed no statistical significance. We concluded that inflammatory cytokines play an important role in JIA. Monitoring IL-6 in children with JIA is useful in determining disease activity and response to therapy. These findings confirm earlier reports.",

keywords = "Cytokine, IL-1, IL-6, Juvenile idiopathic arthritis, Juvenile rheumatoid arthritis, Osteocalcin, TNF-α",

author = "Ou, {L. S.} and See, {L. C.} and Wu, {C. J.} and Kao, {C. C.} and Lin, {Y. L.} and Huang, {J. L.}",

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T1 - Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis

AU - Ou, L. S.

AU - See, L. C.

AU - Wu, C. J.

AU - Kao, C. C.

AU - Lin, Y. L.

AU - Huang, J. L.

PY - 2002

Y1 - 2002

N2 - Circulating interleukin-1β (IL-1β), IL-6, tumour necrosis factor-α (TNF-α), osteocalcin, and conventional parameters of inflammation were examined serially in 14 children with juvenile idiopathic arthritis (JIA) to determine any correlation with the disease activity. Serum IL-1β was undetectable in all JIA patients. Serum IL-6, white blood cell counts, platelet counts, erythrocyte sedimentation rate and C-reactive protein levels were significantly elevated in the active phase of JIA, whereas hemoglobin levels were significantly lower. Osteocalcin levels were decreased and TNF-α increased in active JIA status, but these differences showed no statistical significance. We concluded that inflammatory cytokines play an important role in JIA. Monitoring IL-6 in children with JIA is useful in determining disease activity and response to therapy. These findings confirm earlier reports.

AB - Circulating interleukin-1β (IL-1β), IL-6, tumour necrosis factor-α (TNF-α), osteocalcin, and conventional parameters of inflammation were examined serially in 14 children with juvenile idiopathic arthritis (JIA) to determine any correlation with the disease activity. Serum IL-1β was undetectable in all JIA patients. Serum IL-6, white blood cell counts, platelet counts, erythrocyte sedimentation rate and C-reactive protein levels were significantly elevated in the active phase of JIA, whereas hemoglobin levels were significantly lower. Osteocalcin levels were decreased and TNF-α increased in active JIA status, but these differences showed no statistical significance. We concluded that inflammatory cytokines play an important role in JIA. Monitoring IL-6 in children with JIA is useful in determining disease activity and response to therapy. These findings confirm earlier reports.

KW - Cytokine

KW - IL-1

KW - IL-6

KW - Juvenile idiopathic arthritis

KW - Juvenile rheumatoid arthritis

KW - Osteocalcin

KW - TNF-α

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Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis

Abstract

Keywords

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