Association of Caveolin-1 genotypes with nasopharyngeal carcinoma susceptibility in Taiwan

Yung An Tsou, Chia Wen Tsai, Ming Hsui Tsai, Wen Shin Chang, Fang Jing Li, Yen Fang Liu, Chang Fang Chiu, Cheng Chieh Lin, Da Tian Bau*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

17 Scopus citations

Abstract

Background: Caveolin-1 (Cav-1), which has been proposed as a candidate tumor suppressor, plays a regulatory role in several signaling pathways. High expression of Cav-1 in nasopharyngeal carcinoma (NPC) may enhance tumor cell migration and correlate with poor prognosis of the patients, while the genetic alterations of Cav-1 during nasopharyngeal carcinogenesis are still largely unknown. The aim of this study was to evaluate the association between NPC susceptibility and Cav-1 genotypes. Patients and Methods: One hundred and seventy six patients with NPC and 176 age- and gender-matched healthy controls recruited in Taiwan were genotyped and analyzed by PCR-restriction fragment length polymorphism. Results: There were significant differences between the NPC and control groups in the distributions of the genotypic (p=0.0019) and allelic frequencies (p=2.5*10 -4) in the Cav-1 T29107A (rs7804372) polymorphism. Conclusion: In this first report of Cav-1 involvement in NPC the A allele of Cav-1 T29107A is found to be protective against the development of NPC and may be a novel useful genomic marker for early screening and prediction of NPC.

Original languageEnglish
Pages (from-to)3629-3632
Number of pages4
JournalAnticancer Research
Volume31
Issue number10
StatePublished - 10 2011
Externally publishedYes

Keywords

  • Carcinogenesis
  • Cav-1
  • Nasopharyngeal carcinoma
  • Polymorphism

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