Association of developing childhood epilepsy subsequent to febrile seizure: A population-based cohort study

Lin Mei Chiang, Go Shine Huang, Chi Chin Sun, Ying Li Hsiao, Chung Kun Hui, Mei Hua Hu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations

Abstract

Purpose: Epilepsy is an important neurological condition that frequently associated with neurobehavioral disorders in childhood. Our aim was to identify the risk of developing epilepsy subsequent to febrile seizure and the association between epilepsy risk factors and neurobehavioral disorders. Subjects and methods: This longitudinal population-based cohort data included 952 patients with a febrile seizure diagnosis and 3808 age- and sex-matched controls. Participants were recruited for the study from 1996 to 2011, and all patients were followed up for maximum 12.34 years. Results: The association of epilepsy was significantly higher (18.76-fold) in individuals that experienced febrile seizure compared to controls. Further, of those individuals who experienced febrile seizure, the frequency of subsequent development of epilepsy was 2.15-fold greater in females, 4.846-fold greater in patients with recurrent febrile seizure, and 11.26-fold greater patients with comorbid autism. Conclusions: Our study showed that being female, comorbid autism with febrile seizure and recurrent febrile seizure had an increased association with development of epilepsy. Increased recognition the association for epilepsy might be warranted in those febrile seizure children with certain characteristics.

Original languageEnglish
Pages (from-to)775-780
Number of pages6
JournalBrain and Development
Volume40
Issue number9
DOIs
StatePublished - 10 2018

Bibliographical note

Publisher Copyright:
© 2018 The Japanese Society of Child Neurology

Keywords

  • Autism
  • Comorbidity
  • Epilepsy
  • Recurrent febrile seizure

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