TY - JOUR
T1 - Association of exposure to environmental vanadium and manganese with lung function among young children
T2 - A population-based study
AU - Fan, Nai Chia
AU - Huang, Hsin Yi
AU - Wang, Shih Ling
AU - Tseng, Yu Lun
AU - Chang-Chien, Ju
AU - Tsai, Hui Ju
AU - Yao, Tsung Chieh
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/10/1
Y1 - 2023/10/1
N2 - Exposure to environmental metals has been associated with health outcomes including respiratory health. Little is known about the impact of exposure to environmental metals on lung function among young children in general population. This study aimed to investigate the associations of exposure to metals with lung function among young children in a population-based cohort. A total of 1488 children aged 5–8 years attended a follow-up visit as part of the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort. We measured urinary samples of vanadium (median: 1.21 ng/mL; interquartile range (IQR): 0.73–1.98), manganese (median: 0.23 ng/mL; IQR: 0.13–0.47), arsenic (median: 40.51 ng/mL; IQR: 21.66–70.49), nickel (median: 1.09 ng/mL; IQR: 0.31–3.60), and cadmium (median: 0.26 ng/mL; IQR: 0.11–0.43) and performed lung function tests. Urinary vanadium concentrations were inversely associated with FVC (β coefficient for the highest quartile versus the other quartiles: −33.40, p = 0.001), FEV1 (β: −41.31, p < 0.001), FEV1/FVC ratio (β: −1.00, p = 0.009), PEF (β: −92.12, p = 0.004), and FEF25–75 (β: −82.85, p < 0.001), after adjusting for relevant confounders. Urinary manganese concentrations were inversely associated with FVC (β: −26.60, p = 0.007), FEV1 (β: −31.62, p = 0.001), PEF (β: −84.86, p = 0.009), and FEF25–75 (β: −69.21, p = 0.002). Stratification analyses found inverse associations of urinary vanadium and manganese concentrations with lung function parameters predominantly among children exposed to environmental tobacco smoke. We did not find significant associations of urinary arsenic, nickel, and cadmium concentrations with lung function parameters. In conclusion, this study adds new evidence showing inverse associations of vanadium and manganese exposure with lung function among young children in the general population. Children with environmental tobacco smoke exposure are particularly vulnerable to adverse impact of vanadium and manganese exposure on lung function.
AB - Exposure to environmental metals has been associated with health outcomes including respiratory health. Little is known about the impact of exposure to environmental metals on lung function among young children in general population. This study aimed to investigate the associations of exposure to metals with lung function among young children in a population-based cohort. A total of 1488 children aged 5–8 years attended a follow-up visit as part of the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort. We measured urinary samples of vanadium (median: 1.21 ng/mL; interquartile range (IQR): 0.73–1.98), manganese (median: 0.23 ng/mL; IQR: 0.13–0.47), arsenic (median: 40.51 ng/mL; IQR: 21.66–70.49), nickel (median: 1.09 ng/mL; IQR: 0.31–3.60), and cadmium (median: 0.26 ng/mL; IQR: 0.11–0.43) and performed lung function tests. Urinary vanadium concentrations were inversely associated with FVC (β coefficient for the highest quartile versus the other quartiles: −33.40, p = 0.001), FEV1 (β: −41.31, p < 0.001), FEV1/FVC ratio (β: −1.00, p = 0.009), PEF (β: −92.12, p = 0.004), and FEF25–75 (β: −82.85, p < 0.001), after adjusting for relevant confounders. Urinary manganese concentrations were inversely associated with FVC (β: −26.60, p = 0.007), FEV1 (β: −31.62, p = 0.001), PEF (β: −84.86, p = 0.009), and FEF25–75 (β: −69.21, p = 0.002). Stratification analyses found inverse associations of urinary vanadium and manganese concentrations with lung function parameters predominantly among children exposed to environmental tobacco smoke. We did not find significant associations of urinary arsenic, nickel, and cadmium concentrations with lung function parameters. In conclusion, this study adds new evidence showing inverse associations of vanadium and manganese exposure with lung function among young children in the general population. Children with environmental tobacco smoke exposure are particularly vulnerable to adverse impact of vanadium and manganese exposure on lung function.
KW - Children
KW - Environmental tobacco smoke
KW - Lung function
KW - Manganese
KW - Metal
KW - Vanadium
UR - http://www.scopus.com/inward/record.url?scp=85170095050&partnerID=8YFLogxK
U2 - 10.1016/j.ecoenv.2023.115430
DO - 10.1016/j.ecoenv.2023.115430
M3 - 文章
C2 - 37672937
AN - SCOPUS:85170095050
SN - 0147-6513
VL - 264
JO - Ecotoxicology and Environmental Safety
JF - Ecotoxicology and Environmental Safety
M1 - 115430
ER -
