Abstract
Background: The relation between psoriasis and colorectal cancer (CRC) was largely unclear. Objective: To investigate the association of psoriasis with CRC. Methods: A systematic review and meta-analysis of observational studies that examined the association of psoriasis with CRC was performed. We searched MEDLINE and Embase on March 24, 2020, for relevant studies. The Newcastle-Ottawa scale was used to evaluate the risk of bias of included studies. We conducted a random-effects model meta-analysis and subgroup analysis according to sex. Results: We included 9 cohort studies with 10,544,609 individuals. We found a significantly increased risk for CRC in patients with psoriasis (hazard ratio [HR], 1.16; 95% confidence interval [CI], 1.08-1.24). Subgroups analysis according to sex found significantly increased risk for CRC in female patients with psoriasis (HR, 1.41; 95% CI, 1.16-1.72) but not in male patients (HR, 1.18; 95% CI, 0.92-1.50). Limitations: No data on psoriatic arthritis. Conclusions: Patients with psoriasis have an increased risk for CRC. Gastroenterology consultation and colonoscopic examination are indicated for patients with psoriasis presenting with bowel symptoms.
Original language | English |
---|---|
Pages (from-to) | 1429-1436 |
Number of pages | 8 |
Journal | Journal of the American Academy of Dermatology |
Volume | 85 |
Issue number | 6 |
DOIs | |
State | Published - 12 2021 |
Bibliographical note
Publisher Copyright:© 2020 American Academy of Dermatology, Inc.
Keywords
- cohort study
- colorectal cancer
- meta-analysis
- psoriasis
- risk
- systematic review