Association of psoriasis with colorectal cancer

Yun Fu, Cheng Han Lee, Ching Chi Chi*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

14 Scopus citations

Abstract

Background: The relation between psoriasis and colorectal cancer (CRC) was largely unclear. Objective: To investigate the association of psoriasis with CRC. Methods: A systematic review and meta-analysis of observational studies that examined the association of psoriasis with CRC was performed. We searched MEDLINE and Embase on March 24, 2020, for relevant studies. The Newcastle-Ottawa scale was used to evaluate the risk of bias of included studies. We conducted a random-effects model meta-analysis and subgroup analysis according to sex. Results: We included 9 cohort studies with 10,544,609 individuals. We found a significantly increased risk for CRC in patients with psoriasis (hazard ratio [HR], 1.16; 95% confidence interval [CI], 1.08-1.24). Subgroups analysis according to sex found significantly increased risk for CRC in female patients with psoriasis (HR, 1.41; 95% CI, 1.16-1.72) but not in male patients (HR, 1.18; 95% CI, 0.92-1.50). Limitations: No data on psoriatic arthritis. Conclusions: Patients with psoriasis have an increased risk for CRC. Gastroenterology consultation and colonoscopic examination are indicated for patients with psoriasis presenting with bowel symptoms.

Original languageEnglish
Pages (from-to)1429-1436
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume85
Issue number6
DOIs
StatePublished - 12 2021

Bibliographical note

Publisher Copyright:
© 2020 American Academy of Dermatology, Inc.

Keywords

  • cohort study
  • colorectal cancer
  • meta-analysis
  • psoriasis
  • risk
  • systematic review

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