Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: Interactive effect of MMP9 level

Semon Wu; Lung An Hsu; Ming Sheng Teng; Jeng Feng Lin; Hsien Hsun Chang; Yu Chen Sun; Hsuan Pu Chen; Yu Lin Ko

doi:10.1186/1471-2350-13-115

Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: Interactive effect of MMP9 level

Semon Wu, Lung An Hsu, Ming Sheng Teng, Jeng Feng Lin, Hsien Hsun Chang, Yu Chen Sun, Hsuan Pu Chen, Yu Lin Ko^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

Background: E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.Methods: Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed.Results: SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511).Conclusion: SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.

Original language	English
Article number	115
Journal	BMC Medical Genetics
Volume	13
DOIs	https://doi.org/10.1186/1471-2350-13-115
State	Published - 29 11 2012

Keywords

E-selectin
Genetic association study
Haplotype
Interaction
Matrix metalloproteinase 9
Polymorphism

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10.1186/1471-2350-13-115

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@article{da549a4670654eed9d7270a1c1f43f75,

title = "Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: Interactive effect of MMP9 level",

abstract = "Background: E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.Methods: Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed.Results: SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511).Conclusion: SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.",

keywords = "E-selectin, Genetic association study, Haplotype, Interaction, Matrix metalloproteinase 9, Polymorphism",

author = "Semon Wu and Hsu, {Lung An} and Teng, {Ming Sheng} and Lin, {Jeng Feng} and Chang, {Hsien Hsun} and Sun, {Yu Chen} and Chen, {Hsuan Pu} and Ko, {Yu Lin}",

year = "2012",

month = nov,

day = "29",

doi = "10.1186/1471-2350-13-115",

language = "英语",

volume = "13",

journal = "BMC Medical Genetics",

issn = "1471-2350",

publisher = "BioMed Central Ltd",

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TY - JOUR

T1 - Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals

T2 - Interactive effect of MMP9 level

AU - Wu, Semon

AU - Hsu, Lung An

AU - Teng, Ming Sheng

AU - Lin, Jeng Feng

AU - Chang, Hsien Hsun

AU - Sun, Yu Chen

AU - Chen, Hsuan Pu

AU - Ko, Yu Lin

PY - 2012/11/29

Y1 - 2012/11/29

N2 - Background: E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.Methods: Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed.Results: SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511).Conclusion: SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.

AB - Background: E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.Methods: Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed.Results: SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511).Conclusion: SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.

KW - E-selectin

KW - Genetic association study

KW - Haplotype

KW - Interaction

KW - Matrix metalloproteinase 9

KW - Polymorphism

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DO - 10.1186/1471-2350-13-115

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SN - 1471-2350

VL - 13

JO - BMC Medical Genetics

JF - BMC Medical Genetics

M1 - 115

ER -

Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: Interactive effect of MMP9 level

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