Association of tgf-β1 and il-10 gene polymorphisms with osteoporosis in a study of taiwanese osteoporotic patients

Min Yu Tu, Kuei Yang Han, Ying Wei Lan, Ku Yi Chang, Cheng Wei Lai, Theresa Staniczek, Chung Yu Lai, Kowit Yu Chong*, Chuan Mu Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations


Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-β1- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-β1 SNPs (−509C/T, +869 T/C and +29T/C), one IL-10 SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with TGF-β1 SNP (−509 C/C) and IL-10 SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The TGF-β1 SNP (−509 C/T) genotype in all subjects and TGF-β1 SNP (−509 T/T) and IL-10 SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory TGF-β1 and IL-10 genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of TGF-β1 (−509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women.

Original languageEnglish
Article number930
Issue number6
StatePublished - 06 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Anti-inflammatory cytokine
  • Bone mineral density (BMD)
  • Interleukin-10 (IL-10)
  • Osteoporosis
  • Single-nucleotide polymorphism (SNP)
  • Transforming growth factor-β1 (TGF-β1)


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