Association of TNF-α gene polymorphisms with systemic lupus erythematosus in Taiwanese patients

Ying Ju Lin*, R. H. Chen, L. Wan, J. J.C. Sheu, C. M. Huang, C. W. Lin, S. Y. Chen, C. H. Lai, Y. C. Lan, K. C. Hsueh, C. H. Tsai, T. H. Lin, Y. M. Huang, K. Chao, D. Y. Chen, Fuu Jen Tsai

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

40 Scopus citations

Abstract

Tumour necrosis factor-α (TNF-α), an important proinflammatory cytokine, exerts a variety of physiological and pathogenic effects that lead to tissue destruction. Studies on the association of TNF-α genetic polymorphisms with systemic lupus erythematosus (SLE) have yielded inconclusive results. We investigated the association of TNF-α genetic polymorphisms (-1031T/C, -863C/A, -857T/C, -308A/G and +489A/G) with SLE in Taiwanese patients and controls. Our results indicate that 1) the frequency of the A-allele at -863 position was significantly higher in SLE patients (odds ratio = 1.46; 95% CI = 1.02-2.08); 2) the frequency of the A-allele at +489 position was significantly higher in SLE patients (odds ratio = 1.79; 95% CI = 1.21-2.65); 3) the AA or GA genotype frequencies at +489 position were significantly increased in SLE patients (AA genotype: odds ratio = 11.20; 95% CI = 1.36-92.55; GA genotype: odds ratio = 1.63; 95% CI = 1.03-2.58); 4) no significant association of TNF-α haplotypic distributions was observed, except for the haplotypes TCCGA, CACGA and CCCGG; and 5) the genotype frequency of the polymorphisms at -1031 was significantly different in patients with antinuclear antibodies (P = 0.022). The allele and genotype frequencies of the polymorphisms at -863 were not significantly different. The genotype frequency of the polymorphisms at -857 was significantly different in patients with haematological disorder (P = 0.025). The frequency of A allele of the polymorphisms at -308 was significantly increased in patients with malar rash (P = 0.033), discoid rash (P = 0.023), photosensitivity (P = 0.037), oral ulcers (P = 0.002) and serositis (P = 0.029). The genotype frequency of the polymorphisms at +489 was significantly different in patients with discoid rash and photosensitivity (data not shown; discoid rash, P = 0.031; photosensitivity, P = 0.044). These results suggest that TNF-α genetic polymorphisms contribute to SLE susceptibility in the Taiwanese population.

Original languageEnglish
Pages (from-to)974-979
Number of pages6
JournalLupus
Volume18
Issue number11
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Single nucleotide polymorphism
  • Systemic lupus erythematosus
  • Tumour necrosis factor-α

Fingerprint

Dive into the research topics of 'Association of TNF-α gene polymorphisms with systemic lupus erythematosus in Taiwanese patients'. Together they form a unique fingerprint.

Cite this