Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 µm

Ming Hui Liu, Ming Jen Chan, Ching Wei Hsu, Cheng Hao Weng, Tzung Hai Yen, Wen Hung Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

12 Scopus citations

Abstract

Uremic pruritus (UP) is a common and incapacitating symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is multifactorial and complex. Particulate matter (PM), a major air pollutant, is a mixture of particles with various chemical compositions. PM is associated with several allergic diseases, including dermatitis. To assess the role of PM (PM with a diameter of <10 µm [PM10] and PM with a diameter of <2.5 µm [PM2.5]) and other clinical variables in UP in patients on HD, we recruited 866 patients on maintenance HD (MHD). We analyzed the number of days of mean 24-hour PM10 ≥125 µg/m3/12 months (NDPM10) or the number of days of mean 24-hour PM2.5 ≥35 µg/m3/12 months (NDPM2.5) exceeding the standard level in the past 12 months respectively to determine the association with UP. In a multivariate logistic regression, HD duration, serum ferritin levels, low-density lipoprotein (LDL) levels, and NDPM2.5 ≥116 days/12 months were positively associated with UP. This cross-sectional study showed that the number of days on which the environmental PM2.5 exceeds the standard level might be associated with UP in patients on MHD.

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalTherapeutics and Clinical Risk Management
Volume13
DOIs
StatePublished - 23 02 2017

Bibliographical note

Publisher Copyright:
© 2017 Liu et al.

Keywords

  • Air pollution
  • Environmental particulate matter
  • PM
  • Uremic pruritus

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