Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis

Hsing Fang Lu; Kuo Sheng Hung; Yu Wen Hsu; Yu Ting Tai; Lin Shan Huang; Yu Jia Wang; Henry Sung Ching Wong; Yi Hsiang Hsu; Wei Chiao Chang

doi:10.1371/journal.pone.0140549

Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis

Hsing Fang Lu, Kuo Sheng Hung, Yu Wen Hsu, Yu Ting Tai, Lin Shan Huang, Yu Jia Wang, Henry Sung Ching Wong, Yi Hsiang Hsu, Wei Chiao Chang

Research output: Contribution to journal › Journal Article › peer-review

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Abstract

Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.

Original language	English
Article number	e0140549
Journal	PLoS ONE
Volume	10
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0140549
State	Published - 22 10 2015
Externally published	Yes

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Publisher Copyright:
© 2015 Lu et al This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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title = "Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis",

abstract = "Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.",

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AU - Lu, Hsing Fang

AU - Hung, Kuo Sheng

AU - Hsu, Yu Wen

AU - Tai, Yu Ting

AU - Huang, Lin Shan

AU - Wang, Yu Jia

AU - Wong, Henry Sung Ching

AU - Hsu, Yi Hsiang

AU - Chang, Wei Chiao

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N2 - Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.

AB - Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.

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Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis

Abstract

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