Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure

Chih Chin Kao, Shih Ying Cheng, Mei Yi Wu, Shu Chen Chien, Hsing Fang Lu, Yu Wen Hsu, Yan Feng Zhang, Mai Szu Wu*, Wei Chiao Chang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations

Abstract

Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients. Methods: A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed. Results: In this cohort, 62% (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery. Conclusions: EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.

Original languageEnglish
Article number291
JournalBMC Nephrology
Volume18
Issue number1
DOIs
StatePublished - 07 09 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 The Author(s).

Keywords

  • Cardiovascular
  • Endothelin
  • Renal failure

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