Astragalus Polysaccharides and Metformin May Have Synergistic Effects on the Apoptosis and Ferroptosis of Lung Adenocarcinoma A549 Cells

I. Yun Lee; Ting Chung Wang; Yu Jen Kuo; Wei Tai Shih; Pei Rung Yang; Cheng Ming Hsu; Yu Shih Lin; Ren Shyang Kuo; Ching Yuan Wu

doi:10.3390/cimb46080461

Astragalus Polysaccharides and Metformin May Have Synergistic Effects on the Apoptosis and Ferroptosis of Lung Adenocarcinoma A549 Cells

I. Yun Lee, Ting Chung Wang, Yu Jen Kuo, Wei Tai Shih, Pei Rung Yang, Cheng Ming Hsu, Yu Shih Lin, Ren Shyang Kuo, Ching Yuan Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

Astragalus polysaccharides (APSs), the compounds extracted from the common herb Astragalus membranaceus, have been extensively studied for their antitumor properties. In this study, we investigated the effect of APS on lung adenocarcinoma A549 cells. The effects of APS and the anti-diabetic drug metformin on apoptosis and ferroptosis were compared. Furthermore, the combination treatment of APS and metformin was also investigated. We found that APS not only reduced the growth of lung cancer cells but also had a synergistic effect with metformin on A549 cells. The study results showed that it may be promising to use APS and metformin as a combination therapy for the treatment of lung adenocarcinoma.

Original language	English
Pages (from-to)	7782-7794
Number of pages	13
Journal	Current Issues in Molecular Biology
Volume	46
Issue number	8
DOIs	https://doi.org/10.3390/cimb46080461
State	Published - 23 07 2024

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Publisher Copyright:
© 2024 by the authors.

Keywords

A549 cells
Astragalus polysaccharides (APS)
apoptosis
ferroptosis
lung cancer
metformin

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Astragalus Polysaccharides and Metformin May Have Synergistic Effects on the Apoptosis and Ferroptosis of Lung Adenocarcinoma A549 Cells",

abstract = "Astragalus polysaccharides (APSs), the compounds extracted from the common herb Astragalus membranaceus, have been extensively studied for their antitumor properties. In this study, we investigated the effect of APS on lung adenocarcinoma A549 cells. The effects of APS and the anti-diabetic drug metformin on apoptosis and ferroptosis were compared. Furthermore, the combination treatment of APS and metformin was also investigated. We found that APS not only reduced the growth of lung cancer cells but also had a synergistic effect with metformin on A549 cells. The study results showed that it may be promising to use APS and metformin as a combination therapy for the treatment of lung adenocarcinoma.",

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doi = "10.3390/cimb46080461",

language = "英语",

volume = "46",

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T1 - Astragalus Polysaccharides and Metformin May Have Synergistic Effects on the Apoptosis and Ferroptosis of Lung Adenocarcinoma A549 Cells

AU - Lee, I. Yun

AU - Wang, Ting Chung

AU - Kuo, Yu Jen

AU - Shih, Wei Tai

AU - Yang, Pei Rung

AU - Hsu, Cheng Ming

AU - Lin, Yu Shih

AU - Kuo, Ren Shyang

AU - Wu, Ching Yuan

PY - 2024/7/23

Y1 - 2024/7/23

N2 - Astragalus polysaccharides (APSs), the compounds extracted from the common herb Astragalus membranaceus, have been extensively studied for their antitumor properties. In this study, we investigated the effect of APS on lung adenocarcinoma A549 cells. The effects of APS and the anti-diabetic drug metformin on apoptosis and ferroptosis were compared. Furthermore, the combination treatment of APS and metformin was also investigated. We found that APS not only reduced the growth of lung cancer cells but also had a synergistic effect with metformin on A549 cells. The study results showed that it may be promising to use APS and metformin as a combination therapy for the treatment of lung adenocarcinoma.

AB - Astragalus polysaccharides (APSs), the compounds extracted from the common herb Astragalus membranaceus, have been extensively studied for their antitumor properties. In this study, we investigated the effect of APS on lung adenocarcinoma A549 cells. The effects of APS and the anti-diabetic drug metformin on apoptosis and ferroptosis were compared. Furthermore, the combination treatment of APS and metformin was also investigated. We found that APS not only reduced the growth of lung cancer cells but also had a synergistic effect with metformin on A549 cells. The study results showed that it may be promising to use APS and metformin as a combination therapy for the treatment of lung adenocarcinoma.

KW - A549 cells

KW - Astragalus polysaccharides (APS)

KW - apoptosis

KW - ferroptosis

KW - lung cancer

KW - metformin

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DO - 10.3390/cimb46080461

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SN - 1467-3037

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IS - 8

ER -

Astragalus Polysaccharides and Metformin May Have Synergistic Effects on the Apoptosis and Ferroptosis of Lung Adenocarcinoma A549 Cells

Abstract

Bibliographical note

Keywords

UN SDGs

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