Augmentation of liver regeneration with glucagon after partial hepatectomy in rats

T. L. Hwang*, M. F. Chen, T. J. Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations

Abstract

The direct stimulating effect of glucagon on partially hepatectomized rats was studied. Following a 70% hepatectomy, male Wistar rats were divided into three groups. Group I received glucagon 0.8 mg/kg/day; group II received hydrocortisone 10 mg/kg/day; and group III received normal saline as a control. Their blood sugar levels and food intake were not significantly different. After one week, the regenerated livers in group I were larger (9.69 ± 0.30 cm3 vs 8.29 ± 0.34 cm3 in group II and 8.20 ± 0.10 cm3 in group III), and heavier (9.83 ± 0.28 g vs 8.52 ± 0.33 g in group II and 8.75 ± 0.21 g in group III) than those in the other two groups. The mitotic index in group I was also higher. The results suggest that glucagon has a direct hepatotrophic effect and enhances regeneration of the liver in rats.

Original languageEnglish
Pages (from-to)725-728
Number of pages4
JournalJournal of the Formosan Medical Association
Volume92
Issue number8
StatePublished - 1993
Externally publishedYes

Keywords

  • hepatotrophic effect
  • liver regeneration
  • mitotic index

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