TY - JOUR
T1 - Autistic spectrum disorder, attention deficit hyperactivity disorder, and allergy
T2 - Is there a link? A nationwide study
AU - Lin, Ting Yang
AU - Lin, Pei Yin
AU - Su, Tung Ping
AU - Chen, Ying Sheue
AU - Hsu, Ju Wei
AU - Huang, Kai Lin
AU - Chang, Wen Han
AU - Chen, Tzeng Ji
AU - Pan, Tai Long
AU - Chen, Mu Hong
AU - Bai, Ya Mei
PY - 2014/10
Y1 - 2014/10
N2 - Previous studies showed that both attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD) were associated separately with a higher risk of allergic diseases. However, the comorbid effect of ADHD and ASD on the risk of allergic diseases is still unknown. Using the Taiwan National Health Insurance Research Database, 5386 children aged less than 18 years with ADHD alone, 578 with ASD alone, 458 with ADHD + ASD, and 25,688 non-ADHD/ASD age- and sex-matched (1:4) controls were enrolled in our study. The prevalence of allergic diseases, including asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis, was evaluated among the four groups. Logistic regression analysis showed that the ADHD + ASD group (odds ratio [OR]: 2.26, 95% confidence interval [CI]: 1.83-2.79), ADHD-alone group (OR: 1.81, 95% CI: 1.70-1.93), and ASD-alone group (OR: 1.24, 95% CI: 1.04-1.48) had an increased risk of allergic comorbidities compared to the control after adjusting age, sex, and level of urbanization. ASD children with more allergic comorbidities (≧3: OR: 2.57, 95% CI: 1.74-3.79; 2: OR: 2.00, 95% CI: 1.41-2.84; 1: OR: 1.60, 95% CI: 1.16-2.22) were associated with a greater likelihood of ADHD. Children with ADHD or ASD had an increased risk of allergic comorbidities, and those with both ADHD and ASD had the highest. These results may inspire more research to clarify the underlying mechanisms among ASD, ADHD, and allergic diseases.
AB - Previous studies showed that both attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD) were associated separately with a higher risk of allergic diseases. However, the comorbid effect of ADHD and ASD on the risk of allergic diseases is still unknown. Using the Taiwan National Health Insurance Research Database, 5386 children aged less than 18 years with ADHD alone, 578 with ASD alone, 458 with ADHD + ASD, and 25,688 non-ADHD/ASD age- and sex-matched (1:4) controls were enrolled in our study. The prevalence of allergic diseases, including asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis, was evaluated among the four groups. Logistic regression analysis showed that the ADHD + ASD group (odds ratio [OR]: 2.26, 95% confidence interval [CI]: 1.83-2.79), ADHD-alone group (OR: 1.81, 95% CI: 1.70-1.93), and ASD-alone group (OR: 1.24, 95% CI: 1.04-1.48) had an increased risk of allergic comorbidities compared to the control after adjusting age, sex, and level of urbanization. ASD children with more allergic comorbidities (≧3: OR: 2.57, 95% CI: 1.74-3.79; 2: OR: 2.00, 95% CI: 1.41-2.84; 1: OR: 1.60, 95% CI: 1.16-2.22) were associated with a greater likelihood of ADHD. Children with ADHD or ASD had an increased risk of allergic comorbidities, and those with both ADHD and ASD had the highest. These results may inspire more research to clarify the underlying mechanisms among ASD, ADHD, and allergic diseases.
KW - ADHD
KW - ASD
KW - Allergy
UR - http://www.scopus.com/inward/record.url?scp=84905400944&partnerID=8YFLogxK
U2 - 10.1016/j.rasd.2014.07.009
DO - 10.1016/j.rasd.2014.07.009
M3 - 文章
AN - SCOPUS:84905400944
SN - 1750-9467
VL - 8
SP - 1333
EP - 1338
JO - Research in Autism Spectrum Disorders
JF - Research in Autism Spectrum Disorders
IS - 10
ER -
