Abstract
This study presents a newly designed integrated microfluidic chip capable of detecting two biomarkers, α-defensin-1 (HNP-1) and C-reactive protein (CRP) for periprosthetic joint infection from synovial fluid samples. The magnetic beads-based immunoassays were carried out automatically on a single chip. Experimental results\demonstrated that the standard curves with concentrations ranging from 0.01-50 mg/L for HNP-1 and from 1-100 mg/L for CRP could be successfully achieved, sufficient sensitive for detecting HNP-1 and CRP in synovial fluid.
| Original language | English |
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| Title of host publication | MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 685-686 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419031 |
| State | Published - 2021 |
| Event | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States Duration: 10 10 2021 → 14 10 2021 |
Publication series
| Name | MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
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Conference
| Conference | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 |
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| Country/Territory | United States |
| City | Palm Springs, Virtual |
| Period | 10/10/21 → 14/10/21 |
Bibliographical note
Publisher Copyright:© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
Keywords
- C-Reactive Protein
- Enzyme-Linked Immunosorbent Assay
- Microfluidics
- Periprosthetic Joint Infection
- Synovial Fluid
- α-defensin-1