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Automatic extraction of information about the molecular interactions in biological pathways from texts based on ontology and semantic processing

  • Yu Ting Huang*
  • , Hsiang Yuan Yeh
  • , Shih Wu Cheng
  • , Chien Chih Tu
  • , Chi Li Kuo
  • , Von Wun Soo
  • *Corresponding author for this work
  • National Tsing Hua University
  • National University of Kaohsiung

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations

Abstract

We develop a framework using ontology inference and semantic processing techniques to help biologists to extract knowledge directly from a large scale of biological literature in NCBI PubMed. The system integrated various sharable thesauri of WordNet, MeSH (Medical Subject Heading), and GO (Gene ontology) to support the automatic semantic annotation and analysis. The natural language processing and semantic processing are facilitated by the ontological inference, and the system could automatically extract the correct molecular interactions from the complex sentences in an abstract automatically. It facilitates the biologists not only to save time and efforts to construct and analyze biological pathways, but also to discover the novel molecular interactions by comparing the information extracted from the literature with that in such existing path way database as KEGG. We evaluated the system performance based on the pathways in Apoptosis domain.

Original languageEnglish
Title of host publication2006 IEEE International Conference on Systems, Man and Cybernetics
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3679-3684
Number of pages6
ISBN (Print)1424401003, 9781424401000
DOIs
StatePublished - 2006
Externally publishedYes
Event2006 IEEE International Conference on Systems, Man and Cybernetics - Taipei, Taiwan
Duration: 08 10 200611 10 2006

Publication series

NameConference Proceedings - IEEE International Conference on Systems, Man and Cybernetics
Volume5
ISSN (Print)1062-922X

Conference

Conference2006 IEEE International Conference on Systems, Man and Cybernetics
Country/TerritoryTaiwan
CityTaipei
Period08/10/0611/10/06

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