TY - JOUR
T1 - Autonomic involvement in Wilson's disease
T2 - A study of sympathetic skin response and RR interval variation
AU - Chu, Eric C.
AU - Chu, Nai Shin
AU - Huang, Chin Chang
PY - 1997/8/1
Y1 - 1997/8/1
N2 - Autonomic nervous system involvement in Wilson's disease (WD) was studied in 25 patients by sympathetic skin response (SSR) and RR interval variation (RRIV). The control group consisted of age-matched healthy subjects. Palmar SSRs were obtained by central activation from median nerve stimulation and by activation of sympathetic trunk from magnetic stimulation of the neck. Electric SSRs were prolonged in 11 patients and absent in 2; magnetic SSRs were delayed in 4 and absent in 1; and the sympathetic central conduction time was prolonged in 3. The mean latencies and mean central conduction of the SSRs were all significantly prolonged in WD when compared to the control group. On the other hand, parasympathetic function was abnormal in 3 patients only during forced deep breathing, and as a group only mean D% was significantly reduced. The present findings suggest that autonomic dysfunction may occur in WD, and that sympathetic function is predominantly affected, mainly due to central involvement.
AB - Autonomic nervous system involvement in Wilson's disease (WD) was studied in 25 patients by sympathetic skin response (SSR) and RR interval variation (RRIV). The control group consisted of age-matched healthy subjects. Palmar SSRs were obtained by central activation from median nerve stimulation and by activation of sympathetic trunk from magnetic stimulation of the neck. Electric SSRs were prolonged in 11 patients and absent in 2; magnetic SSRs were delayed in 4 and absent in 1; and the sympathetic central conduction time was prolonged in 3. The mean latencies and mean central conduction of the SSRs were all significantly prolonged in WD when compared to the control group. On the other hand, parasympathetic function was abnormal in 3 patients only during forced deep breathing, and as a group only mean D% was significantly reduced. The present findings suggest that autonomic dysfunction may occur in WD, and that sympathetic function is predominantly affected, mainly due to central involvement.
KW - Autonomic nervous system
KW - RR interval variation
KW - Sympathetic skin response
KW - Wilson's disease
UR - http://www.scopus.com/inward/record.url?scp=0030994160&partnerID=8YFLogxK
U2 - 10.1016/S0022-510X(97)05365-3
DO - 10.1016/S0022-510X(97)05365-3
M3 - 文章
C2 - 9171319
AN - SCOPUS:0030994160
SN - 0022-510X
VL - 149
SP - 131
EP - 137
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 2
ER -