TY - JOUR
T1 - B-group vitamins, MTHFR C677T polymorphism and carotid intima-media thickness in clinically healthy subjects
AU - Liu, C. S.
AU - Chen, C. H.
AU - Chiang, H. C.
AU - Kuo, C. L.
AU - Huang, C. S.
AU - Cheng, W. L.
AU - Wei, Y. H.
AU - Chen, H. W.
PY - 2007/8
Y1 - 2007/8
N2 - Objective: Plasma B-group vitamins and age may affect the carotid intima-media thickness (IMT) in subjects with different 677TT genotype of the methylenetetrahydrofolate reductase (MTHFR) gene. Design: A hospital-based cross-study. Setting: Genomic and Vascular Center, Changhua Christian Hospital, Changhua, Taiwan. Subjects: Five hundred and forty-one clinically healthy subjects. Intervention: Fasting plasma, homocysteine (Hcy), vitamin B6, vitamin B12, folate and B-mode carotid ultrasound. Results: MTHFR genotype, plasma concentrations of folate, vitamin B6 and vitamin B12 and age were significantly correlated to the plasma Hcy concentration. MTHFR 677TT carriers had higher concentrations of Hcy than did subjects with the CC and CT genotypes. Age, sex, body mass index and plasma Hcy were independent contributors to increase carotid IMT. However, with stratification by mean value of age and B-group vitamins concentrations, we found that at advanced age, lower plasma folate and vitamin B12 were three risk factors involved in the enhancing effect of the MTHFR 677TT genotype on the increase of plasma Hcy and carotid IMT. Conclusion: MTHFR 677TT-related carotid atherosclerosis was only identified in healthy elderly subjects with lower level of plasma folate and vitamin B12.
AB - Objective: Plasma B-group vitamins and age may affect the carotid intima-media thickness (IMT) in subjects with different 677TT genotype of the methylenetetrahydrofolate reductase (MTHFR) gene. Design: A hospital-based cross-study. Setting: Genomic and Vascular Center, Changhua Christian Hospital, Changhua, Taiwan. Subjects: Five hundred and forty-one clinically healthy subjects. Intervention: Fasting plasma, homocysteine (Hcy), vitamin B6, vitamin B12, folate and B-mode carotid ultrasound. Results: MTHFR genotype, plasma concentrations of folate, vitamin B6 and vitamin B12 and age were significantly correlated to the plasma Hcy concentration. MTHFR 677TT carriers had higher concentrations of Hcy than did subjects with the CC and CT genotypes. Age, sex, body mass index and plasma Hcy were independent contributors to increase carotid IMT. However, with stratification by mean value of age and B-group vitamins concentrations, we found that at advanced age, lower plasma folate and vitamin B12 were three risk factors involved in the enhancing effect of the MTHFR 677TT genotype on the increase of plasma Hcy and carotid IMT. Conclusion: MTHFR 677TT-related carotid atherosclerosis was only identified in healthy elderly subjects with lower level of plasma folate and vitamin B12.
UR - http://www.scopus.com/inward/record.url?scp=34547636713&partnerID=8YFLogxK
U2 - 10.1038/sj.ejcn.1602606
DO - 10.1038/sj.ejcn.1602606
M3 - 文章
C2 - 17228344
AN - SCOPUS:34547636713
SN - 0954-3007
VL - 61
SP - 996
EP - 1003
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 8
ER -