Beilschamide, a New Amide, and Cytotoxic Constituents of Beilschmiedia erythrophloia

Jih Jung Chen; Wen Lung Kuo; Ping Jyun Sung; Ih Sheng Chen; Ming Jen Cheng; Yun Ping Lim; Hsiang Ruei Liao; Tsung Hsien Chang; Dau Chang Wei; Jhy Yih Chen

doi:10.1007/s10600-015-1265-0

Beilschamide, a New Amide, and Cytotoxic Constituents of Beilschmiedia erythrophloia

Jih Jung Chen^*, Wen Lung Kuo, Ping Jyun Sung, Ih Sheng Chen, Ming Jen Cheng, Yun Ping Lim, Hsiang Ruei Liao, Tsung Hsien Chang, Dau Chang Wei, Jhy Yih Chen

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

A new amide, beilschamide (1), has been isolated from the stem of Beilschmiedia erythrophloia, together with seven known compounds, N-trans-feruloyltyramine (2), N-trans-feruloyloctopamine (3), vanillin (4), α-tocopheryl quinone (5), β-sitostenone (6), β-sitosterol (7), and 6α-hydroxystigmast-4-en-3-one (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. N-trans-Feruloyloctopamine (3) and beilschamide (1) exhibited cytotoxic effects with IC₅₀ values of 10.3 and 21.2 μg/mL, respectively, against CCRF-CEM cell line.

Original language	English
Pages (from-to)	302-305
Number of pages	4
Journal	Chemistry of Natural Compounds
Volume	51
Issue number	2
DOIs	https://doi.org/10.1007/s10600-015-1265-0
State	Published - 01 03 2015

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Publisher Copyright:
© 2015 Springer Science+Business Media New York.

Keywords

Beilschmiedia erythrophloia
amide
beilschamide

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10.1007/s10600-015-1265-0

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title = "Beilschamide, a New Amide, and Cytotoxic Constituents of Beilschmiedia erythrophloia",

abstract = "A new amide, beilschamide (1), has been isolated from the stem of Beilschmiedia erythrophloia, together with seven known compounds, N-trans-feruloyltyramine (2), N-trans-feruloyloctopamine (3), vanillin (4), α-tocopheryl quinone (5), β-sitostenone (6), β-sitosterol (7), and 6α-hydroxystigmast-4-en-3-one (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. N-trans-Feruloyloctopamine (3) and beilschamide (1) exhibited cytotoxic effects with IC50 values of 10.3 and 21.2 μg/mL, respectively, against CCRF-CEM cell line.",

keywords = "Beilschmiedia erythrophloia, amide, beilschamide",

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doi = "10.1007/s10600-015-1265-0",

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T1 - Beilschamide, a New Amide, and Cytotoxic Constituents of Beilschmiedia erythrophloia

AU - Chen, Jih Jung

AU - Kuo, Wen Lung

AU - Sung, Ping Jyun

AU - Chen, Ih Sheng

AU - Cheng, Ming Jen

AU - Lim, Yun Ping

AU - Liao, Hsiang Ruei

AU - Chang, Tsung Hsien

AU - Wei, Dau Chang

AU - Chen, Jhy Yih

PY - 2015/3/1

Y1 - 2015/3/1

N2 - A new amide, beilschamide (1), has been isolated from the stem of Beilschmiedia erythrophloia, together with seven known compounds, N-trans-feruloyltyramine (2), N-trans-feruloyloctopamine (3), vanillin (4), α-tocopheryl quinone (5), β-sitostenone (6), β-sitosterol (7), and 6α-hydroxystigmast-4-en-3-one (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. N-trans-Feruloyloctopamine (3) and beilschamide (1) exhibited cytotoxic effects with IC50 values of 10.3 and 21.2 μg/mL, respectively, against CCRF-CEM cell line.

AB - A new amide, beilschamide (1), has been isolated from the stem of Beilschmiedia erythrophloia, together with seven known compounds, N-trans-feruloyltyramine (2), N-trans-feruloyloctopamine (3), vanillin (4), α-tocopheryl quinone (5), β-sitostenone (6), β-sitosterol (7), and 6α-hydroxystigmast-4-en-3-one (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. N-trans-Feruloyloctopamine (3) and beilschamide (1) exhibited cytotoxic effects with IC50 values of 10.3 and 21.2 μg/mL, respectively, against CCRF-CEM cell line.

KW - Beilschmiedia erythrophloia

KW - amide

KW - beilschamide

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DO - 10.1007/s10600-015-1265-0

M3 - 文章

AN - SCOPUS:84953351697

SN - 0009-3130

VL - 51

SP - 302

EP - 305

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

IS - 2

ER -

Beilschamide, a New Amide, and Cytotoxic Constituents of Beilschmiedia erythrophloia

Abstract

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Keywords

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