Bidirectional associations between psoriasis and migraine: A systematic review and meta-analysis

I. Hsin Huang, Wei Kai Hung, Ching Chi Chi*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


Background and Objectives: To evaluate the association between psoriasis and migraine. Patients and Methods: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched for relevant observational studies from their respective inception to May 1, 2022. A random-effects model meta-analysis was performed to calculate the risk estimates quantifying the associations between psoriasis and migraine. We also performed a sensitivity analysis by including only studies with adjusted risk estimates and a subgroup analysis according to the severity of psoriasis. Results: We included 9 studies with 6,742,075 participants. The meta-analysis illustrated increased odds for prevalent migraine among patients with psoriasis (pooled OR: 1.69, 95% CI: 1.26–2.28) and increased odds for prevalent psoriasis among those with migraine (OR: 1.88, 95% CI: 1.32–3.67). A subgroup analysis of cohort studies demonstrated an increasingly higher risk of incident migraine in patients with mild psoriasis and severe psoriasis (IRR being 1.37 (95% CI 1.30–1.44) and 1.55 (95% CI 1.29–1.86), respectively). Conclusions: This meta-analysis revealed significant bidirectional associations between migraine and psoriasis. Greater severity of psoriasis appears to be associated with a higher risk of developing migraine. Clinicians should evaluate symptoms of migraine in patients with psoriasis and provide proper treatments.

Original languageEnglish
Pages (from-to)493-502
Number of pages10
JournalJDDG - Journal of the German Society of Dermatology
Issue number5
StatePublished - 05 2023

Bibliographical note

© 2023 Deutsche Dermatologische Gesellschaft (DDG).


  • Humans
  • Migraine Disorders/epidemiology
  • Psoriasis/epidemiology
  • Cohort Studies


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