Bioactive cembrane diterpenoids of anisomeles indica

Yu Li Chen; Yu Hsuan Lan; Pei Wen Hsieh; Chin Chung Wu; Shu Li Chen; Chiao Ting Yen; Fang Rong Chang; Wen Chun Hung; Yang Chang Wu

doi:10.1021/np800147z

Bioactive cembrane diterpenoids of anisomeles indica

Yu Li Chen, Yu Hsuan Lan, Pei Wen Hsieh, Chin Chung Wu, Shu Li Chen, Chiao Ting Yen, Fang Rong Chang^*, Wen Chun Hung, Yang Chang Wu

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

60 Scopus citations

Abstract

Five new cembrane-type diterpenoids with a tram-fused α-methylene-y- lactone (1-5), a new flavonoid glucoside (6), and 17 known compounds were isolated from a methanol extract of Anisomeles indica. The structures of 1-6 were elucidated by spectroscopic analysis, and the absolute configuration of compound 1 was determined using the modified Mosher's method. Compound 8 (4,5-epoxovatodiolide) exhibited cytotoxicity against a small panel of human cancer cell lines. Additionally, compounds 4 and 7 (ovatodiolide) exhibited selective antiplatelet aggregation activities toward collagen, while compounds 4, 5, and 8 showed inhibitory effects on antiplatelet aggregation induced by thrombin.

Original language	English
Pages (from-to)	1207-1212
Number of pages	6
Journal	Journal of Natural Products
Volume	71
Issue number	7
DOIs	https://doi.org/10.1021/np800147z
State	Published - 07 2008
Externally published	Yes

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title = "Bioactive cembrane diterpenoids of anisomeles indica",

abstract = "Five new cembrane-type diterpenoids with a tram-fused α-methylene-y- lactone (1-5), a new flavonoid glucoside (6), and 17 known compounds were isolated from a methanol extract of Anisomeles indica. The structures of 1-6 were elucidated by spectroscopic analysis, and the absolute configuration of compound 1 was determined using the modified Mosher's method. Compound 8 (4,5-epoxovatodiolide) exhibited cytotoxicity against a small panel of human cancer cell lines. Additionally, compounds 4 and 7 (ovatodiolide) exhibited selective antiplatelet aggregation activities toward collagen, while compounds 4, 5, and 8 showed inhibitory effects on antiplatelet aggregation induced by thrombin.",

author = "Chen, \{Yu Li\} and Lan, \{Yu Hsuan\} and Hsieh, \{Pei Wen\} and Wu, \{Chin Chung\} and Chen, \{Shu Li\} and Yen, \{Chiao Ting\} and Chang, \{Fang Rong\} and Hung, \{Wen Chun\} and Wu, \{Yang Chang\}",

year = "2008",

month = jul,

doi = "10.1021/np800147z",

language = "英语",

volume = "71",

pages = "1207--1212",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Bioactive cembrane diterpenoids of anisomeles indica

AU - Chen, Yu Li

AU - Lan, Yu Hsuan

AU - Hsieh, Pei Wen

AU - Wu, Chin Chung

AU - Chen, Shu Li

AU - Yen, Chiao Ting

AU - Chang, Fang Rong

AU - Hung, Wen Chun

AU - Wu, Yang Chang

PY - 2008/7

Y1 - 2008/7

N2 - Five new cembrane-type diterpenoids with a tram-fused α-methylene-y- lactone (1-5), a new flavonoid glucoside (6), and 17 known compounds were isolated from a methanol extract of Anisomeles indica. The structures of 1-6 were elucidated by spectroscopic analysis, and the absolute configuration of compound 1 was determined using the modified Mosher's method. Compound 8 (4,5-epoxovatodiolide) exhibited cytotoxicity against a small panel of human cancer cell lines. Additionally, compounds 4 and 7 (ovatodiolide) exhibited selective antiplatelet aggregation activities toward collagen, while compounds 4, 5, and 8 showed inhibitory effects on antiplatelet aggregation induced by thrombin.

AB - Five new cembrane-type diterpenoids with a tram-fused α-methylene-y- lactone (1-5), a new flavonoid glucoside (6), and 17 known compounds were isolated from a methanol extract of Anisomeles indica. The structures of 1-6 were elucidated by spectroscopic analysis, and the absolute configuration of compound 1 was determined using the modified Mosher's method. Compound 8 (4,5-epoxovatodiolide) exhibited cytotoxicity against a small panel of human cancer cell lines. Additionally, compounds 4 and 7 (ovatodiolide) exhibited selective antiplatelet aggregation activities toward collagen, while compounds 4, 5, and 8 showed inhibitory effects on antiplatelet aggregation induced by thrombin.

UR - https://www.scopus.com/pages/publications/49049107730

U2 - 10.1021/np800147z

DO - 10.1021/np800147z

M3 - 文章

C2 - 18547115

AN - SCOPUS:49049107730

SN - 0163-3864

VL - 71

SP - 1207

EP - 1212

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 7

ER -

Bioactive cembrane diterpenoids of anisomeles indica

Abstract

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