Bioactive compounds from a gorgonian coral Echinomuricea sp. (Plexauridae)

Hsu Ming Chung, Pei Han Hong, Jui Hsin Su, Tsong Long Hwang, Mei Chin Lu, Lee Shing Fang, Yang Chang Wu, Jan Jung Li, Jih Jung Chen, Wei Hsien Wang*, Ping Jyun Sung

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

18 Scopus citations

Abstract

A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ- lactone ring by a hemiketal moiety, and this compound is the first labdane-type diterpenoid to be obtained from marine organisms belonging to the phylum Cnidaria. 6-epi-Yonarasterol B (2) is the first steroid derivative to be isolated from gorgonian coral belonging to the genus Echinomuricea, and this compound displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.

Original languageEnglish
Pages (from-to)1169-1179
Number of pages11
JournalMarine Drugs
Volume10
Issue number5
DOIs
StatePublished - 05 2012

Keywords

  • Echinolabdane
  • Echinomuricea
  • Elastase
  • Superoxide anion
  • Yonarasterol

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