Bioactive diterpenes from Callicarpa longissima

Yuan Wei Liu; Yuan Bin Cheng; Chia Ching Liaw; Chung Hsiung Chen; Jih Hwa Guh; Tsong Long Hwang; Ji Shu Tsai; Won Bo Wang; Ya Ching Shen

doi:10.1021/np200932k

Bioactive diterpenes from Callicarpa longissima

Yuan Wei Liu, Yuan Bin Cheng, Chia Ching Liaw, Chung Hsiung Chen, Jih Hwa Guh, Tsong Long Hwang, Ji Shu Tsai, Won Bo Wang, Ya Ching Shen^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

National Taiwan University

Research output: Contribution to journal › Journal Article › peer-review

35 Scopus citations

Abstract

Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (1-4), callilongisins A-D, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6β-hydroxylabda-8(17), 13-dien-15-oic acid, 5-hydroxy-3,6,7,4′-tetramethoxyflavone, and artemetin. Compounds 1-3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated.

Original language	English
Pages (from-to)	689-693
Number of pages	5
Journal	Journal of Natural Products
Volume	75
Issue number	4
DOIs	https://doi.org/10.1021/np200932k
State	Published - 27 04 2012

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title = "Bioactive diterpenes from Callicarpa longissima",

abstract = "Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (1-4), callilongisins A-D, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6β-hydroxylabda-8(17), 13-dien-15-oic acid, 5-hydroxy-3,6,7,4′-tetramethoxyflavone, and artemetin. Compounds 1-3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated.",

author = "Liu, {Yuan Wei} and Cheng, {Yuan Bin} and Liaw, {Chia Ching} and Chen, {Chung Hsiung} and Guh, {Jih Hwa} and Hwang, {Tsong Long} and Tsai, {Ji Shu} and Wang, {Won Bo} and Shen, {Ya Ching}",

year = "2012",

month = apr,

day = "27",

doi = "10.1021/np200932k",

language = "英语",

volume = "75",

pages = "689--693",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "4",

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TY - JOUR

T1 - Bioactive diterpenes from Callicarpa longissima

AU - Liu, Yuan Wei

AU - Cheng, Yuan Bin

AU - Liaw, Chia Ching

AU - Chen, Chung Hsiung

AU - Guh, Jih Hwa

AU - Hwang, Tsong Long

AU - Tsai, Ji Shu

AU - Wang, Won Bo

AU - Shen, Ya Ching

PY - 2012/4/27

Y1 - 2012/4/27

N2 - Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (1-4), callilongisins A-D, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6β-hydroxylabda-8(17), 13-dien-15-oic acid, 5-hydroxy-3,6,7,4′-tetramethoxyflavone, and artemetin. Compounds 1-3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated.

AB - Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (1-4), callilongisins A-D, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6β-hydroxylabda-8(17), 13-dien-15-oic acid, 5-hydroxy-3,6,7,4′-tetramethoxyflavone, and artemetin. Compounds 1-3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated.

UR - http://www.scopus.com/inward/record.url?scp=84860340216&partnerID=8YFLogxK

U2 - 10.1021/np200932k

DO - 10.1021/np200932k

M3 - 文章

C2 - 22429052

AN - SCOPUS:84860340216

SN - 0163-3864

VL - 75

SP - 689

EP - 693

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Bioactive diterpenes from Callicarpa longissima

Abstract

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