TY - JOUR
T1 - Bioactive Isoprenoid-Derived Natural Products from a Dongsha Atoll Soft Coral Sinularia erecta
AU - Huang, Chiung Yao
AU - Tseng, Yen Ju
AU - Chokkalingam, Uvarani
AU - Hwang, Tsong Long
AU - Hsu, Chi Hsin
AU - Dai, Chang Feng
AU - Sung, Ping Jyun
AU - Sheu, Jyh Horng
N1 - Publisher Copyright:
© 2016 The American Chemical Society and American Society of Pharmacognosy.
PY - 2016/5/27
Y1 - 2016/5/27
N2 - Four new isoprenoids, including two norcembranoids sinulerectols A and B (1 and 2), a cembranoid sinulerectol C (3), and a degraded cembranoid sinulerectadione (4), along with three known isoprenoids, an unnamed norcembrene (5), sinularectin (6), and ineleganolide (7), and a known nitrogen-containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8), were isolated from an extract of the marine soft coral Sinularia erecta. The structure of sinularectin (6) was revised, too. Compounds 3, 4, and 8 exhibited inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 1, 2, and 8 displayed potent anti-inflammatory activity in fMLP/CB-stimulated human neutrophils.
AB - Four new isoprenoids, including two norcembranoids sinulerectols A and B (1 and 2), a cembranoid sinulerectol C (3), and a degraded cembranoid sinulerectadione (4), along with three known isoprenoids, an unnamed norcembrene (5), sinularectin (6), and ineleganolide (7), and a known nitrogen-containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8), were isolated from an extract of the marine soft coral Sinularia erecta. The structure of sinularectin (6) was revised, too. Compounds 3, 4, and 8 exhibited inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 1, 2, and 8 displayed potent anti-inflammatory activity in fMLP/CB-stimulated human neutrophils.
UR - http://www.scopus.com/inward/record.url?scp=84971449677&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.5b01142
DO - 10.1021/acs.jnatprod.5b01142
M3 - 文章
C2 - 27142697
AN - SCOPUS:84971449677
SN - 0163-3864
VL - 79
SP - 1339
EP - 1346
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -
