Bioactive Isoprenoid-Derived Natural Products from a Dongsha Atoll Soft Coral Sinularia erecta

Chiung Yao Huang; Yen Ju Tseng; Uvarani Chokkalingam; Tsong Long Hwang; Chi Hsin Hsu; Chang Feng Dai; Ping Jyun Sung; Jyh Horng Sheu

doi:10.1021/acs.jnatprod.5b01142

Bioactive Isoprenoid-Derived Natural Products from a Dongsha Atoll Soft Coral Sinularia erecta

Chiung Yao Huang
, Yen Ju Tseng
, Uvarani Chokkalingam
, Tsong Long Hwang
, Chi Hsin Hsu
, Chang Feng Dai
, Ping Jyun Sung
, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

National Sun Yat-sen University
National Taiwan University
National Museum of Marine Biology and Aquarium, Taiwan
Kaohsiung Medical University
China Medical University Taichung

Research output: Contribution to journal › Journal Article › peer-review

42 Scopus citations

Abstract

Four new isoprenoids, including two norcembranoids sinulerectols A and B (1 and 2), a cembranoid sinulerectol C (3), and a degraded cembranoid sinulerectadione (4), along with three known isoprenoids, an unnamed norcembrene (5), sinularectin (6), and ineleganolide (7), and a known nitrogen-containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8), were isolated from an extract of the marine soft coral Sinularia erecta. The structure of sinularectin (6) was revised, too. Compounds 3, 4, and 8 exhibited inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 1, 2, and 8 displayed potent anti-inflammatory activity in fMLP/CB-stimulated human neutrophils.

Original language	English
Pages (from-to)	1339-1346
Number of pages	8
Journal	Journal of Natural Products
Volume	79
Issue number	5
DOIs	https://doi.org/10.1021/acs.jnatprod.5b01142
State	Published - 27 05 2016

Bibliographical note

Publisher Copyright:
© 2016 The American Chemical Society and American Society of Pharmacognosy.

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title = "Bioactive Isoprenoid-Derived Natural Products from a Dongsha Atoll Soft Coral Sinularia erecta",

abstract = "Four new isoprenoids, including two norcembranoids sinulerectols A and B (1 and 2), a cembranoid sinulerectol C (3), and a degraded cembranoid sinulerectadione (4), along with three known isoprenoids, an unnamed norcembrene (5), sinularectin (6), and ineleganolide (7), and a known nitrogen-containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8), were isolated from an extract of the marine soft coral Sinularia erecta. The structure of sinularectin (6) was revised, too. Compounds 3, 4, and 8 exhibited inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 1, 2, and 8 displayed potent anti-inflammatory activity in fMLP/CB-stimulated human neutrophils.",

author = "Huang, \{Chiung Yao\} and Tseng, \{Yen Ju\} and Uvarani Chokkalingam and Hwang, \{Tsong Long\} and Hsu, \{Chi Hsin\} and Dai, \{Chang Feng\} and Sung, \{Ping Jyun\} and Sheu, \{Jyh Horng\}",

note = "Publisher Copyright: {\textcopyright} 2016 The American Chemical Society and American Society of Pharmacognosy.",

year = "2016",

month = may,

day = "27",

doi = "10.1021/acs.jnatprod.5b01142",

language = "英语",

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T1 - Bioactive Isoprenoid-Derived Natural Products from a Dongsha Atoll Soft Coral Sinularia erecta

AU - Huang, Chiung Yao

AU - Tseng, Yen Ju

AU - Chokkalingam, Uvarani

AU - Hwang, Tsong Long

AU - Hsu, Chi Hsin

AU - Dai, Chang Feng

AU - Sung, Ping Jyun

AU - Sheu, Jyh Horng

PY - 2016/5/27

Y1 - 2016/5/27

N2 - Four new isoprenoids, including two norcembranoids sinulerectols A and B (1 and 2), a cembranoid sinulerectol C (3), and a degraded cembranoid sinulerectadione (4), along with three known isoprenoids, an unnamed norcembrene (5), sinularectin (6), and ineleganolide (7), and a known nitrogen-containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8), were isolated from an extract of the marine soft coral Sinularia erecta. The structure of sinularectin (6) was revised, too. Compounds 3, 4, and 8 exhibited inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 1, 2, and 8 displayed potent anti-inflammatory activity in fMLP/CB-stimulated human neutrophils.

AB - Four new isoprenoids, including two norcembranoids sinulerectols A and B (1 and 2), a cembranoid sinulerectol C (3), and a degraded cembranoid sinulerectadione (4), along with three known isoprenoids, an unnamed norcembrene (5), sinularectin (6), and ineleganolide (7), and a known nitrogen-containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8), were isolated from an extract of the marine soft coral Sinularia erecta. The structure of sinularectin (6) was revised, too. Compounds 3, 4, and 8 exhibited inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 1, 2, and 8 displayed potent anti-inflammatory activity in fMLP/CB-stimulated human neutrophils.

UR - https://www.scopus.com/pages/publications/84971449677

U2 - 10.1021/acs.jnatprod.5b01142

DO - 10.1021/acs.jnatprod.5b01142

M3 - 文章

C2 - 27142697

AN - SCOPUS:84971449677

SN - 0163-3864

VL - 79

SP - 1339

EP - 1346

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Bioactive Isoprenoid-Derived Natural Products from a Dongsha Atoll Soft Coral Sinularia erecta

Abstract

Bibliographical note

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