Bioactive new withanolides from the cultured soft coral Sinularia brassica

Chiung Yao Huang; Atallah F. Ahmed; Jui Hsin Su; Ping Jyun Sung; Tsong Long Hwang; Pei Lun Chiang; Chang Feng Dai; Chih Chuang Liaw; Jyh Horng Sheu

doi:10.1016/j.bmcl.2017.06.029

Bioactive new withanolides from the cultured soft coral Sinularia brassica

Chiung Yao Huang, Atallah F. Ahmed, Jui Hsin Su, Ping Jyun Sung, Tsong Long Hwang, Pei Lun Chiang, Chang Feng Dai, Chih Chuang Liaw, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

21 Scopus citations

Abstract

Continuing study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H–L (1–5). The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxicities of new compounds 1–5 and a known compound sinubrasolide A (6) against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of compounds 1–6 were evaluated by measuring their ability to suppress N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils.

Original language	English
Pages (from-to)	3267-3271
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	27
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2017.06.029
State	Published - 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

Anti-inflammatory activity
Cytotoxicity
Sinularia brassica
Soft coral
Withanolide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2017.06.029

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title = "Bioactive new withanolides from the cultured soft coral Sinularia brassica",

abstract = "Continuing study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H–L (1–5). The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxicities of new compounds 1–5 and a known compound sinubrasolide A (6) against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of compounds 1–6 were evaluated by measuring their ability to suppress N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils.",

keywords = "Anti-inflammatory activity, Cytotoxicity, Sinularia brassica, Soft coral, Withanolide",

author = "Huang, {Chiung Yao} and Ahmed, {Atallah F.} and Su, {Jui Hsin} and Sung, {Ping Jyun} and Hwang, {Tsong Long} and Chiang, {Pei Lun} and Dai, {Chang Feng} and Liaw, {Chih Chuang} and Sheu, {Jyh Horng}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.bmcl.2017.06.029",

language = "英语",

volume = "27",

pages = "3267--3271",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "15",

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TY - JOUR

T1 - Bioactive new withanolides from the cultured soft coral Sinularia brassica

AU - Huang, Chiung Yao

AU - Ahmed, Atallah F.

AU - Su, Jui Hsin

AU - Sung, Ping Jyun

AU - Hwang, Tsong Long

AU - Chiang, Pei Lun

AU - Dai, Chang Feng

AU - Liaw, Chih Chuang

AU - Sheu, Jyh Horng

PY - 2017

Y1 - 2017

N2 - Continuing study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H–L (1–5). The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxicities of new compounds 1–5 and a known compound sinubrasolide A (6) against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of compounds 1–6 were evaluated by measuring their ability to suppress N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils.

AB - Continuing study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H–L (1–5). The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxicities of new compounds 1–5 and a known compound sinubrasolide A (6) against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of compounds 1–6 were evaluated by measuring their ability to suppress N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils.

KW - Anti-inflammatory activity

KW - Cytotoxicity

KW - Sinularia brassica

KW - Soft coral

KW - Withanolide

UR - http://www.scopus.com/inward/record.url?scp=85021127830&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2017.06.029

DO - 10.1016/j.bmcl.2017.06.029

M3 - 文章

C2 - 28648460

AN - SCOPUS:85021127830

SN - 0960-894X

VL - 27

SP - 3267

EP - 3271

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Bioactive new withanolides from the cultured soft coral Sinularia brassica

Abstract

Bibliographical note

Keywords

UN SDGs

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