Bioactive steroids from the Formosan soft coral Umbellulifera petasites

Chiung Yao Huang, Che Wei Chang, Yen Ju Tseng, Jessica Lee, Ping Jyun Sung, Jui Hsin Su, Tsong Long Hwang, Chang Feng Dai, Hui Chun Wang, Jyh Horng Sheu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

27 Scopus citations

Abstract

Three new steroids, petasitosterones A and B (1 and 2) and a spirosteroid petasitosterone C (3), along with eight known steroids (4-11), were isolated from a Formosan marine soft coral Umbellulifera petasites. The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound 3 is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds 1-3 and 5 displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas 2 and 5 exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds 1-11 were also examined to evaluate the anti-inflammatory potential, and 2-4 were shown to exhibit significant activities.

Original languageEnglish
Article number180
JournalMarine Drugs
Volume14
Issue number10
DOIs
StatePublished - 10 2016

Bibliographical note

Publisher Copyright:
© 2016 by the authors.

Keywords

  • Anti-inflammatory activity
  • Cytotoxic activity
  • Soft coral
  • Steroid
  • Umbellulifera petasites

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