Bioactive taxanes from the roots of Taxus mairei

Ya Ching Shen; Hung Ru Tai; Pei Wen Hsieh; Ching Yeu Chen

Bioactive taxanes from the roots of Taxus mairei

Ya Ching Shen^*, Hung Ru Tai, Pei Wen Hsieh, Ching Yeu Chen

^*Corresponding author for this work

National Sun Yat-sen University

Research output: Contribution to journal › Journal Article › peer-review

18 Scopus citations

Abstract

Nine taxoids including 1-dehydroxybaccatin VI (1), baccatin VI (2), 1-dehydroxybaccatin IV (3), 5α,7β,9α,10β,13α-pentaacetoxy-taxa-4(20),11-diene (4), 2-deacetoxydecinnamoyl taxinine J (5), 2-deacetoxytaxinine J (6), taxinine J (7), 10-deacetyltaxol C (8) and 10-deacetyltaxol (9) were isolated from the ethanolic extract of the roots of Formosan Taxus mairei. Their structures were established primarily on the basis of NMR studies. Biological studies revealed that compounds 8 and 9 exhibited potent cytotoxicities against human KB-16, A-549 and HT-29 tumor cells.

Original language	English
Pages (from-to)	207-217
Number of pages	11
Journal	Chinese Pharmaceutical Journal
Volume	48
Issue number	3
State	Published - 06 1996
Externally published	Yes

Keywords

Taxaceae
Taxus mairei
cytotoxicity
taxoids

Cite this

@article{013eff69410745349fa433d0c246a252,

title = "Bioactive taxanes from the roots of Taxus mairei",

abstract = "Nine taxoids including 1-dehydroxybaccatin VI (1), baccatin VI (2), 1-dehydroxybaccatin IV (3), 5α,7β,9α,10β,13α-pentaacetoxy-taxa-4(20),11-diene (4), 2-deacetoxydecinnamoyl taxinine J (5), 2-deacetoxytaxinine J (6), taxinine J (7), 10-deacetyltaxol C (8) and 10-deacetyltaxol (9) were isolated from the ethanolic extract of the roots of Formosan Taxus mairei. Their structures were established primarily on the basis of NMR studies. Biological studies revealed that compounds 8 and 9 exhibited potent cytotoxicities against human KB-16, A-549 and HT-29 tumor cells.",

keywords = "Taxaceae, Taxus mairei, cytotoxicity, taxoids",

author = "Shen, {Ya Ching} and Tai, {Hung Ru} and Hsieh, {Pei Wen} and Chen, {Ching Yeu}",

year = "1996",

month = jun,

language = "英语",

volume = "48",

pages = "207--217",

journal = "Chinese Pharmaceutical Journal",

issn = "1016-1015",

publisher = "Pharmaceutical Society of Republic of China",

number = "3",

}

TY - JOUR

T1 - Bioactive taxanes from the roots of Taxus mairei

AU - Shen, Ya Ching

AU - Tai, Hung Ru

AU - Hsieh, Pei Wen

AU - Chen, Ching Yeu

PY - 1996/6

Y1 - 1996/6

N2 - Nine taxoids including 1-dehydroxybaccatin VI (1), baccatin VI (2), 1-dehydroxybaccatin IV (3), 5α,7β,9α,10β,13α-pentaacetoxy-taxa-4(20),11-diene (4), 2-deacetoxydecinnamoyl taxinine J (5), 2-deacetoxytaxinine J (6), taxinine J (7), 10-deacetyltaxol C (8) and 10-deacetyltaxol (9) were isolated from the ethanolic extract of the roots of Formosan Taxus mairei. Their structures were established primarily on the basis of NMR studies. Biological studies revealed that compounds 8 and 9 exhibited potent cytotoxicities against human KB-16, A-549 and HT-29 tumor cells.

AB - Nine taxoids including 1-dehydroxybaccatin VI (1), baccatin VI (2), 1-dehydroxybaccatin IV (3), 5α,7β,9α,10β,13α-pentaacetoxy-taxa-4(20),11-diene (4), 2-deacetoxydecinnamoyl taxinine J (5), 2-deacetoxytaxinine J (6), taxinine J (7), 10-deacetyltaxol C (8) and 10-deacetyltaxol (9) were isolated from the ethanolic extract of the roots of Formosan Taxus mairei. Their structures were established primarily on the basis of NMR studies. Biological studies revealed that compounds 8 and 9 exhibited potent cytotoxicities against human KB-16, A-549 and HT-29 tumor cells.

KW - Taxaceae

KW - Taxus mairei

KW - cytotoxicity

KW - taxoids

UR - http://www.scopus.com/inward/record.url?scp=0029993871&partnerID=8YFLogxK

M3 - 文章

AN - SCOPUS:0029993871

SN - 1016-1015

VL - 48

SP - 207

EP - 217

JO - Chinese Pharmaceutical Journal

JF - Chinese Pharmaceutical Journal

IS - 3

ER -

Bioactive taxanes from the roots of Taxus mairei

Abstract

Keywords

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