Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity

Shih Huang Tai; Ping Chung Kuo; Ching Che Hung; Ying Hsuan Lin; Tsong Long Hwang; Sio Hong Lam; Daih Huang Kuo; Jin Bin Wu; Hsin Yi Hung; Tian Shung Wu

doi:10.1039/c9ra05899k

Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity

Shih Huang Tai, Ping Chung Kuo, Ching Che Hung, Ying Hsuan Lin, Tsong Long Hwang, Sio Hong Lam, Daih Huang Kuo, Jin Bin Wu, Hsin Yi Hung, Tian Shung Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC₅₀ values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

Original language	English
Pages (from-to)	34184-34195
Number of pages	12
Journal	RSC Advances
Volume	9
Issue number	59
DOIs	https://doi.org/10.1039/c9ra05899k
State	Published - 2019

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© 2019 The Royal Society of Chemistry.

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title = "Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity",

abstract = "Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.",

author = "Tai, {Shih Huang} and Kuo, {Ping Chung} and Hung, {Ching Che} and Lin, {Ying Hsuan} and Hwang, {Tsong Long} and Lam, {Sio Hong} and Kuo, {Daih Huang} and Wu, {Jin Bin} and Hung, {Hsin Yi} and Wu, {Tian Shung}",

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year = "2019",

doi = "10.1039/c9ra05899k",

language = "英语",

volume = "9",

pages = "34184--34195",

journal = "RSC Advances",

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T2 - Fomitopsis pinicola and their anti-inflammatory activity

AU - Tai, Shih Huang

AU - Kuo, Ping Chung

AU - Hung, Ching Che

AU - Lin, Ying Hsuan

AU - Hwang, Tsong Long

AU - Lam, Sio Hong

AU - Kuo, Daih Huang

AU - Wu, Jin Bin

AU - Hung, Hsin Yi

AU - Wu, Tian Shung

PY - 2019

Y1 - 2019

N2 - Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

AB - Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

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DO - 10.1039/c9ra05899k

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Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity

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