Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity

Shih Huang Tai; Ping Chung Kuo; Ching Che Hung; Ying Hsuan Lin; Tsong Long Hwang; Sio Hong Lam; Daih Huang Kuo; Jin Bin Wu; Hsin Yi Hung; Tian Shung Wu

doi:10.1039/c9ra05899k

Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity

Shih Huang Tai
, Ping Chung Kuo
, Ching Che Hung
, Ying Hsuan Lin
, Tsong Long Hwang
, Sio Hong Lam
, Daih Huang Kuo
, Jin Bin Wu
, Hsin Yi Hung
, Tian Shung Wu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

National Cheng Kung University
University of California at Riverside
Tajen University
Jen-Li Biotechnology Company

Research output: Contribution to journal › Journal Article › peer-review

10 Scopus citations

Abstract

Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC₅₀ values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

Original language	English
Pages (from-to)	34184-34195
Number of pages	12
Journal	RSC Advances
Volume	9
Issue number	59
DOIs	https://doi.org/10.1039/c9ra05899k
State	Published - 2019

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© 2019 The Royal Society of Chemistry.

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title = "Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity",

abstract = "Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.",

author = "Tai, \{Shih Huang\} and Kuo, \{Ping Chung\} and Hung, \{Ching Che\} and Lin, \{Ying Hsuan\} and Hwang, \{Tsong Long\} and Lam, \{Sio Hong\} and Kuo, \{Daih Huang\} and Wu, \{Jin Bin\} and Hung, \{Hsin Yi\} and Wu, \{Tian Shung\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9ra05899k",

language = "英语",

volume = "9",

pages = "34184--34195",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of

T2 - Fomitopsis pinicola and their anti-inflammatory activity

AU - Tai, Shih Huang

AU - Kuo, Ping Chung

AU - Hung, Ching Che

AU - Lin, Ying Hsuan

AU - Hwang, Tsong Long

AU - Lam, Sio Hong

AU - Kuo, Daih Huang

AU - Wu, Jin Bin

AU - Hung, Hsin Yi

AU - Wu, Tian Shung

PY - 2019

Y1 - 2019

N2 - Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

AB - Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

UR - https://www.scopus.com/pages/publications/85074451203

U2 - 10.1039/c9ra05899k

DO - 10.1039/c9ra05899k

M3 - 文章

AN - SCOPUS:85074451203

SN - 2046-2069

VL - 9

SP - 34184

EP - 34195

JO - RSC Advances

JF - RSC Advances

IS - 59

ER -

Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity

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