Bioavailability of magnetic nanoparticles to the brain

Bor Ren Huang, Pin Yuan Chen, Chiung Yin Huang, Shih Ming Jung, Yunn Hwa Ma, Tony Wu, Jyh Ping Chen*, Kuo Chen Wei

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

14 Scopus citations

Abstract

This study investigates the bioavailability of carboxymethyl dextran-coated magnetic nanoparticles (CMD-MNP) to the brain. The cytotoxicity of CMD-MNP was assessed by co-culture with C6, a rat glioma cell line. To investigate the effects of an external magnetic field on the biodistribution of nanoparticles in a rat model, a magnet of 0.3 Tesla was applied externally over the cranium and the particles injected via the external jugular vein. Nanoparticles were also injected into rats implanted with C6 tumor cells. Staining of histological samples with Prussian blue to detect iron particles revealed that the external magnetic field enhanced the aggregation of nanoparticles in the rat brain; this enhancement was even more pronounced in the tumor region.

Original languageEnglish
Pages (from-to)1604-1609
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Volume321
Issue number10
DOIs
StatePublished - 05 2009

Keywords

  • Drug carrier
  • Glioma
  • Magnetics
  • Nanoparticle
  • Tissue distribution

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