Abstract
This study investigates the bioavailability of carboxymethyl dextran-coated magnetic nanoparticles (CMD-MNP) to the brain. The cytotoxicity of CMD-MNP was assessed by co-culture with C6, a rat glioma cell line. To investigate the effects of an external magnetic field on the biodistribution of nanoparticles in a rat model, a magnet of 0.3 Tesla was applied externally over the cranium and the particles injected via the external jugular vein. Nanoparticles were also injected into rats implanted with C6 tumor cells. Staining of histological samples with Prussian blue to detect iron particles revealed that the external magnetic field enhanced the aggregation of nanoparticles in the rat brain; this enhancement was even more pronounced in the tumor region.
Original language | English |
---|---|
Pages (from-to) | 1604-1609 |
Number of pages | 6 |
Journal | Journal of Magnetism and Magnetic Materials |
Volume | 321 |
Issue number | 10 |
DOIs | |
State | Published - 05 2009 |
Keywords
- Drug carrier
- Glioma
- Magnetics
- Nanoparticle
- Tissue distribution