Biodegradable cable-tie rapamycin-eluting stents

Cheng Hung Lee, Ming Jer Hsieh, Shang Hung Chang, Chang Lin Chiang, Ching Lung Fan, Shih Jung Liu*, Wei Jan Chen, Chao Jan Wang, Ming Yi Hsu, Kuo Chun Hung, Chung Chuan Chou, Po Cheng Chang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

9 Scopus citations


“Cable-tie” type biodegradable stents with drug-eluting nanofiber were developed to treat rabbit denuded arteries in this study. Biodegradable stents were fabricated using poly-L-lactide film following being cut and rolled into a cable-tie type stent. Additionally, drug-eluting biodegradable nanofiber tubes were electrospun from a solution containing poly (lactic-co-glycolic acid), rapamycin, and hexafluoroisopropanol, and then mounted onto the stents. The fabricated rapamycin-eluting cable-tie stents exhibited excellent mechanical properties on evaluation of compression test and collapse pressure, and less than 8% weight loss following being immersed in phosphate-buffered saline for 16 weeks. Furthermore, the biodegradable stents delivered high rapamycin concentrations for over 4 weeks and achieved substantial reductions in intimal hyperplasia associated with elevated heme oxygenase-1 and calponin level on the denuded rabbit arteries during 6 months of follow-up. The drug-eluting cable-tie type stents developed in this study might have high potential impacts for the local drug delivery to treat various vascular diseases.

Original languageEnglish
Article number111
JournalScientific Reports
Issue number1
StatePublished - 2017

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© The Author(s) 2017.


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