Biologic properties of three newly established human esophageal carcinoma cell lines

Cheng po Hu; Hsian guey Hsieh; Kwang yu Chien; Pei yen Wang; Ching i. Wang; Chih yi Chen; Szecheng J. Lo; Kuang dong Wuu; Chungming Chang

doi:10.1093/jnci/72.3.577

Biologic properties of three newly established human esophageal carcinoma cell lines

Cheng po Hu^*
, Hsian guey Hsieh
, Kwang yu Chien
, Pei yen Wang
, Ching i. Wang
, Chih yi Chen
, Szecheng J. Lo
, Kuang dong Wuu
, Chungming Chang

^*Corresponding author for this work

Veterans General Hospital-Taipei
National Yang Ming Chiao Tung University
Kaohsiung General Veterans Hospital

Research output: Contribution to journal › Journal Article › peer-review

72 Scopus citations

Abstract

Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.

Original language	English
Pages (from-to)	577-583
Number of pages	7
Journal	Journal of the National Cancer Institute
Volume	72
Issue number	3
DOIs	https://doi.org/10.1093/jnci/72.3.577
State	Published - 03 1984
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1093/jnci/72.3.577

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title = "Biologic properties of three newly established human esophageal carcinoma cell lines",

abstract = "Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.",

author = "Hu, \{Cheng po\} and Hsieh, \{Hsian guey\} and Chien, \{Kwang yu\} and Wang, \{Pei yen\} and Wang, \{Ching i.\} and Chen, \{Chih yi\} and Lo, \{Szecheng J.\} and Wuu, \{Kuang dong\} and Chungming Chang",

year = "1984",

month = mar,

doi = "10.1093/jnci/72.3.577",

language = "英语",

volume = "72",

pages = "577--583",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

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}

TY - JOUR

T1 - Biologic properties of three newly established human esophageal carcinoma cell lines

AU - Hu, Cheng po

AU - Hsieh, Hsian guey

AU - Chien, Kwang yu

AU - Wang, Pei yen

AU - Wang, Ching i.

AU - Chen, Chih yi

AU - Lo, Szecheng J.

AU - Wuu, Kuang dong

AU - Chang, Chungming

PY - 1984/3

Y1 - 1984/3

N2 - Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.

AB - Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.

UR - https://www.scopus.com/pages/publications/0021344920

U2 - 10.1093/jnci/72.3.577

DO - 10.1093/jnci/72.3.577

M3 - 文章

C2 - 6583441

AN - SCOPUS:0021344920

SN - 0027-8874

VL - 72

SP - 577

EP - 583

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 3

ER -

Biologic properties of three newly established human esophageal carcinoma cell lines

Abstract

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