Biomarkers associated with vascular and valvular calcification in chronic hemodialysis patients

Chien Te Lee*, Sarah Chua, Chung Yao Hsu, Yu Che Tsai, Hwee Yeong Ng, Chien Chun Kuo, Chien Hsing Wu, Te Chun Chen, Terry Ting Yu Chiu, Yueh Ting Lee

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

33 Scopus citations

Abstract

Background: Cardiovascular calcification, including arterial intimal and medial calcification (AIC and AMC) and valvular calcification (VC) are important predictors of outcome in chronic dialysis patients. We aimed to compare their prevalence and analyze respective risk factors in hemodialysis (HD) patients. Methods: A total of 81 HD patients were enrolled. Vascular calcification was assessed by plain film radiography of the pelvis and VC was diagnosed by echocardiography. Demographic data was reviewed and serum levels of calcification-relevant biomarkers were determined. Patients with and without calcification were then compared. Results: The prevalence study indicated that 36 patients had AIC (44.4%), 17 had AMC (21%) and 60 (74.1%) had VC. Patients with vascular calcification were older, and had a higher prevalence of diabetes. Their IL-6, osteoprotegerin, and uric acid levels were higher. Serum fetuin-A was lower in patients with VC. Logistic regression analysis revealed age, uric acid and diabetes to be independently associated with AIC; uric acid, diabetes and osteoprotegerin with AMC. Fetuin-A was the sole associate of VC. Conclusions: It is concluded that the prevalence of cardiovascular calcification in chronic HD patients was high with cardiac valve involvement more frequent. Factors associated with different type of calcification were not identical. Changes in biomarkers may represent clinical clues for assessment of cardiovascular calcification in HD patients.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalDisease Markers
Volume34
Issue number4
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Vascular calcification
  • biomarker
  • hemodialysis
  • valvular calcification

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