Abstract
Aim: To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs). Materials and Methods: A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay kits. PMODs were diagnosed in accordance with the World Health Organization (WHO) guidelines. Results: A significant association between a high level of 8-ISO and an increased risk of PMODs was identified [odds ratio (OR)=1.71, 95% confidence interval (CI)=1.12-2.63; p=0.013]. This positive association was stronger among patients with PMOD subtype of leukoplakia (OR=1.94, 95% Cl=1.24-3.06; p=0.004). However, no significant association was observed between plasma 8-OHdG levels and overall risk of PMODs or subtypes. Conclusion: Our findings suggest that increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia.
Original language | English |
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Pages (from-to) | 4661-4666 |
Number of pages | 6 |
Journal | Anticancer Research |
Volume | 38 |
Issue number | 8 |
DOIs | |
State | Published - 08 2018 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2018 International Institute of Anticancer Research. All rights reserved.
Keywords
- Biomarkers
- Leukoplakia
- Oxidative stress
- Potentially malignant oral disorders