Biomarkers of oxidative stress associated with the risk of potentially malignant oral disorders

Thomas Senghore, Yu Feng Li, Fung Chang Sung, Ming Hsui Tsai, Chun Hung Hua, Chiu Shong Liu, Ru Jiun Huang, Chih Ching Yeh*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

Aim: To investigate the effect of oxidative stress biomarkers on the risk of potentially malignant oral disorders (PMODs). Materials and Methods: A total of 208 male adults with PMODs and an equal number of same-age control patients were enrolled. Plasma biomarkers of oxidative stress, measured with 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), were determined using enzyme-linked immunosorbent assay kits. PMODs were diagnosed in accordance with the World Health Organization (WHO) guidelines. Results: A significant association between a high level of 8-ISO and an increased risk of PMODs was identified [odds ratio (OR)=1.71, 95% confidence interval (CI)=1.12-2.63; p=0.013]. This positive association was stronger among patients with PMOD subtype of leukoplakia (OR=1.94, 95% Cl=1.24-3.06; p=0.004). However, no significant association was observed between plasma 8-OHdG levels and overall risk of PMODs or subtypes. Conclusion: Our findings suggest that increased plasma 8-ISO levels may indicate the prominence of lipid peroxidation in the development of PMODs, particularly leukoplakia.

Original languageEnglish
Pages (from-to)4661-4666
Number of pages6
JournalAnticancer Research
Volume38
Issue number8
DOIs
StatePublished - 08 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 International Institute of Anticancer Research. All rights reserved.

Keywords

  • Biomarkers
  • Leukoplakia
  • Oxidative stress
  • Potentially malignant oral disorders

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