Abstract
Since the introduction of the first monoclonal antibody, biopharmaceuticals and biotherapeutic products manufactured in cellular factories are on the rise in modern medicine and therapeutics. Dynamic and real-time innovation strategies for operational implementation of biotherapeutic production are rapidly emerging. The advances in related fields such as genome editing technology, systems biology, and machine learning/artificial intelligence are expected to introduce innovative solutions in every aspect of the mammalian cell culture-based biotherapeutic production. This conceptual review offers a synthesis of the prospects and challenges of integration of multiomics technologies, and an integrative biology vision to cellular factories and biotherapeutic innovation.
| Original language | English |
|---|---|
| Pages (from-to) | 621-633 |
| Number of pages | 13 |
| Journal | OMICS A Journal of Integrative Biology |
| Volume | 24 |
| Issue number | 11 |
| DOIs | |
| State | Published - 11 2020 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© Copyright 2020, Mary Ann Liebert, Inc., publishers 2020.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 9 Industry, Innovation, and Infrastructure
Keywords
- artificial intelligence
- biotherapeutics
- machine learning
- metabolic engineering
- metabolomics
- multiomics
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