Blood lead level is a positive predictor of uremic pruritus in patients undergoing hemodialysis

Cheng Hao Weng, Ching Wei Hsu, Ching Chih Hu, Tzung Hai Yen, Ming Jen Chan, Wen Hung Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

10 Scopus citations


Although uremic pruritus (UP) is a common and annoying symptom for end-stage renal disease patients on hemodialysis (HD) and peritoneal dialysis, its pathogenesis is poorly understood. However, systemic inflammation is one of the possible pathogenesis of UP, and blood lead level (BLL) has been noted to be associated with inflammation and nutritional status in long-term HD patients. There might be an interaction or association, therefore, between BLL and UP through systemic inflammation. We analyzed cross-sectional data among 866 participants. All of the 866 patients in this study were stratified into groups with low-normal (<10 μg/dL), high-normal (10-20 μg/dL), and abnormal BLLs (>20 μg/dL). The associations between UP and BLL and the clinical data were analyzed. Multivariate logistic regression demonstrated that HD duration, non-anuria, log ferritin, serum low-density lipoprotein, log BLL, high-normal BLL, and high BLL were associated with UP. In conclusion, BLL was positively associated with UP.

Original languageEnglish
Pages (from-to)717-723
Number of pages7
JournalTherapeutics and Clinical Risk Management
StatePublished - 12 06 2017

Bibliographical note

Publisher Copyright:
© 2017 Weng et al.


  • Blood lead levels
  • Hemodialysis
  • Uremic pruritus


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