Blueberry muffin baby with acute myeloid leukemia and spontaneous remission

Ya Wen Hsiao, Fang Wen Tseng, Yi Ling Shih, Tseng Tong Kuo, Tang Her Jaing, Rosaline Chung Yee Hui*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations


Blueberry muffin baby is a rare neonatal skin disorder. Causes for the generalized hemorrhagic purpuric eruptions include congenital infections, hemolysis, and tumors. We report a 2.5-month-old female baby with a blueberry muffin appearance, respiratory distress, and decreased activity and appetite. Skin biopsy showed diffuse infiltrates of myeloperoxidase- and lysozyme-positive blast-like cells in dermis and superficial subcutis. Bone marrow study confirmed the diagnosis of acute monocytic leukemia with leukemia cutis. The skin nodules regressed spontaneously without chemotherapy over several days, and the peripheral blood cell counts normalized. This spontaneous remission lasted for 2 months. Spontaneous remission of infantile leukemia is rare, and its mechanism remains unknown. Although overt leukemia relapsed in some of these patients, a delay in chemotherapy spared these infants of the toxic effects of treatment.

Original languageEnglish
Pages (from-to)47-49
Number of pages3
JournalDermatologica Sinica
Issue number2
StatePublished - 06 2011
Externally publishedYes


  • Blueberry muffin baby
  • Leukemia
  • Spontaneous remission


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