Bone Metastasis in Endemic Nasopharyngeal Carcinoma: 18F-Fluorodeoxyglucose-Positron Emission Tomography

Feng Yuan Liu*, Tzu Chen Yen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Nasopharyngeal carcinoma (NPC) occurs from the epithelial lining of the nasopharynx. Anatomically, the nasopharynx is bounded anteriorly by the nasal choanae, superiorly by the sphenoid, and posteriorly by the clivus and the first two cervical vertebrae. There is a striking difference in the sensitivity to radiotherapy and chemotherapy between the early and later courses of treatment for NPC. Early detection, accurate staging, and optimal initial treatment are the keys to improve survival of NPC patients. FDG-PET or PET-CT may be valuable in providing more accurate primary staging. FDG-PET is superior to bone scintigraphy in the detection of osteolytic metastases. In contrast, osteoblastic metastases show lower metabolic activity and are frequently undetectable by PET. In osteoblastic metastases, there are usually fewer tumor cells and the tumor activity may be lower than that in osteolytic lesions. For prostate cancer, FDG-PET is limited in detecting lymph node and soft tissue metastases. The lesions identified by FDG-PET only evolved into active lesions on bone scan thereafter, while those lesions identified by bone scan only remained stationary. It is possible that FDG-avid lesions were more active or aggressive and non-FDG-avid lesions were stable or regressive. 18F-fluoride PET-CT is considered to be a more sensitive and specific modality for detecting bone metastases in prostate cancer.

Original languageEnglish
Title of host publicationCancer Imaging
PublisherElsevier
Pages321-326
Number of pages6
ISBN (Print)9780123742124
DOIs
StatePublished - 05 12 2007
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2008 Elsevier Inc. All rights reserved.

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